Open, single-blind, double-blind: which peer review process do you prefer?
© Moylan et al.; licensee BioMed Central Ltd. 2014
Received: 4 September 2014
Accepted: 10 September 2014
Published: 30 September 2014
BMC Pharmacology and Toxicology was created from the merger of two journals within the BMC series published by BioMed Central: BMC Pharmacology and BMC Clinical Pharmacology. BMC Pharmacology operated anonymous peer review whereas BMC Clinical Pharmacology operated a fully open peer review policy where the identity of the reviewers was known to the editors, authors and readers. The merged journal also adopted a fully open peer review policy. Two years on we discuss the views and experiences of our Editorial Board Members towards open peer review on this biomedical journal.
The story so far
The BMC series of journals was established in 2000 by BioMed Central to provide open access to research published across a range of disciplines in biology and medicine . Over the years, new journals have been launched to fulfil a particular research need (BMC Veterinary Research 2005, BMC Systems Biology 2007 and BMC Psychology 2013 are among such examples). All the biology journals within the BMC series operate traditional anonymous peer review, where the authors do not know who the reviewers are. However, the medical journals were established with open peer review, where the identity of the reviewers is known to all parties – editors, authors and readers .
Two years ago the pharmacology titles in the BMC series, BMC Pharmacology (a biology journal) and BMC Clinical Pharmacology (a medical journal), joined forces under the new title BMC Pharmacology and Toxicology. The combined journal retained the full scopes of the original titles while also expanding to explicitly include the field of toxicology. Many of the original Editorial Board Members remained associated with the journal, and new academics and clinicians also joined.
In merging a biology journal operating anonymous peer review with a medical journal operating open peer review, we debated what the peer review process should be on BMC Pharmacology and Toxicology. In the end, the journal naturally retained the open peer review policy previously adopted by BMC Clinical Pharmacology – in keeping with all the other medical titles in the BMC series. BMC Cancer, another journal in the BMC series with biology and medicine disciplines, also operates open peer review.
Under open peer review, authors know who reviewed their manuscript (reviewer reports are signed) and, if the manuscript is published, the reader will also see the reviewers’ comments and the authors’ response. These comments are published as part of the ‘pre-publication history’ accompanying the published article, which also contains all versions of the manuscript and (where relevant) editors’ comments. By making the peer review process completely transparent we aim to reduce the competing interests that can occur especially for a journal which frequently publishes research sponsored by pharmaceutical companies . See this recent article  for an example of a pre-publication history .
While many have recently discussed the benefits of open peer review including transparency, accountability and giving credit to reviewers [7–11], there are challenges too. Potential reviewers may be more likely to decline to review  and some (junior) reviewers may be reluctant to sign a critical report [13, 14]. There are field-specific differences too. Medical disciplines with the particular need to be transparent about treatments for patients and competing interests appear to be more willing to embrace open peer review than the biological sciences. However, within biology there are differences between research fields, too: for example, the bioinformatics and genomics communities seem to accept open peer review more readily than traditional subjects such as immunology and physiology . Perhaps this reflects their familiarity with features of open-source software and social-networking technologies .
At the time of the merger of BMC Pharmacology and BMC Clinical Pharmacology, we said that we would report on our findings of open peer review with the resulting biomedical journal. So, two years down the line, how have things fared with BMC Pharmacology and Toxicology?
Our survey says…
Survey questions to the BMC Pharmacology & Toxicology Editorial Board
Is your area of expertise in medicine or biology?
If medicine, are you a clinical academic or full time academic?
How many years have you been working as an academic?
Choose one that best describes you:
I was on the original board of BMC Clinical Pharmacology
I was on the original board of BMC Pharmacology
I joined the editorial board of BMC Pharmacology and Toxicology within the last 2 years.
As an author, have you published in an open peer review journal? (meaning that the reviewers’ identity was revealed to you as an author)
4a (if yes) Do you think reports were less/equally/more useful to you than those from a closed peer review journal? If you have never published in a closed peer review journal please go to the next question.
4b (if no) Would you consider publishing in an open peer review journal? (if no, why?)
As a reviewer which peer review system do you prefer, and why?
5a Open (authors and reading public know reviewers’ identity)
5b single-blind (i.e. reviewers know authors’ identity but not vice versa)
5c double-blind (i.e. authors and reviewers do not know each other’s identity)
As a handling editor do you prefer a different (from your answer to question 5) model of peer review?
6a (If yes), which model do you prefer and why do you have a different preference as an editor compared to as a reviewer?
As a reader do you look at the pre-publication histories on BMC Pharmacology and Toxicology (or any of the open peer review journals in the BMC series)?
7a If no, why not?
7b If yes, what is your main reason for looking at the pre-publication history?
Do you have any further comments on open peer review?
Definitions of open, single-blind and double-blind peer review as operated by BioMed Central
Open peer review
Editors, authors and reviewers know each other’s identity. If the manuscript is published, the reviewer reports, any editors’ comments, authors’ response and all versions of the manuscript are available via an accompanying ‘pre-publication history’.
Single-blind peer review
Reviewers know authors’ identity but not vice versa.
Double-blind peer review
Authors and reviewers do not know each other’s identity
The survey has provided a sample of the views and experiences of academics and clinicians with respect to peer review on a biomedical journal, and as a result we appreciate there are improvements which can be made. However, this small survey has some limitations too. The low response rate limits the generalizability of the findings; we were not able to draw any specific conclusions reflecting (for example) the attitudes of particular groups based on gender/subject background/seniority towards different systems of peer review.
So two years into the open peer review experiment on BMC Pharmacology and Toxicology, will we continue to operate an open peer review system? Put simply: yes.
Among the Editorial Board Members who responded to our survey, there appears to be an overall preference for a peer review system that is double-blind (where authors and reviewers are not revealed to each other). Other much larger surveys have also come to similar conclusions [17, 19, 20]. However, it is unclear if this is a genuine feeling among researchers or rather ‘wishful thinking’ that double-blind peer review intuitively seems the fairest approach . Certainly not many biology and medical journals operate double-blind peer review and from a pragmatic view point it is difficult to prevent reviewers from guessing who the authors are.
We will continue with open peer review at BMC Pharmacology and Toxicology because of the ethical grounds for doing so  and because the potential benefits outweigh the negatives [22, 23]. Open peer review provides a fully transparent pre-publication history, and the reading public can see who reviewed the manuscript and what was said. Having access to peer reviews also provides valuable information for training purposes [24, 25] and allows further research into the benefits of peer review . And by making peer review completely open and reviewers (and editors) accountable, we aim to reduce the competing interests that can occur. But perhaps more relevant, in this era of ‘predatory publishers’  and ‘sting’ operations  open peer review ensures that the decision-making process is fully transparent for all to see.
From the feedback we receive more generally from authors on our open peer review journals in the BMC series, many value the helpfulness, quality and detail of the reports. But given the responses received from our Editorial Board Members we need to make more of the fact that the pre-publication history is provided for readers and what it contains.
If you have any further feedback on the open peer review policy operated by BMC Pharmacology and Toxicology we’d certainly welcome your comments.
ECM is the Biology Editor at BioMed Central. SH is an Associate Editor at Nature Communications. CON is Associate Publisher at BioMed Central and Editor of Biome. MK is the Deputy Biology Editor at BioMed Central.
Our thanks to Paul Lambert for contacting the Editorial Board; Caroline Black, Scott Edmunds, Christopher Morrey and Jigisha Patel for their comments on the text; and the Editorial Board Members of BMC Pharmacology and Toxicology for their participation in this survey.
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