Basic pharmacology

Section edited by David Farb

This section considers submissions that focus on receptor pharmacology, signal transduction, pharmacokinetics and pharmacogenomics relating to all organ systems.

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  1. Research article

    Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells

    Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patie...

    Yu-Guang Ma, Jun-Wei Wang, Yun-Gang Bai, Mei Liu, Man-Jiang Xie and Zhi-Jun Dai

    BMC Pharmacology and Toxicology 2017 18:30

    Published on: 26 April 2017

  2. Research article

    Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

    The objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats.

    Anayt Ulla, Mustafe Khalid Mohamed, Biswajit Sikder, AFM Towheedur Rahman, Farzana Akther Sumi, Murad Hossain, Hasan Mahmud Reza, G. M. Sayedur Rahman and Md Ashraful Alam

    BMC Pharmacology and Toxicology 2017 18:29

    Published on: 20 April 2017

  3. Research article

    Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460

    Side-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (N...

    Seon Young Choi, Hang-Rae Kim, Pan Dong Ryu and So Yeong Lee

    BMC Pharmacology and Toxicology 2017 18:14

    Published on: 21 February 2017

  4. Research article

    5-aminolevulinic acid combined with ferrous ion reduces adiposity and improves glucose tolerance in diet-induced obese mice via enhancing mitochondrial function

    Mitochondrial dysfunction is associated with obesity and various obesity-associated pathological conditions including glucose intolerance. 5-Aminolevulinic acid (ALA), a precursor of heme metabolites, is a nat...

    Urara Ota, Takeshi Hara, Hitoshi Nakagawa, Emi Tsuru, Masayuki Tsuda, Atsuko Kamiya, Yasushi Kuroda, Yuya Kitajima, Aya Koda, Masahiro Ishizuka, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Motowo Nakajima and Tohru Tanaka

    BMC Pharmacology and Toxicology 2017 18:7

    Published on: 30 January 2017

  5. Research article

    Synthetic and natural antioxidants attenuate cisplatin-induced vomiting

    Synthetic and natural antioxidants including Bacopa monnieri (L.) Pennell (Scrophulariaceae) which also possess anti-dopaminergic properties, have been proposed to be useful for emetogenic chemotherapy. In this s...

    Javaid Alam, Fazal Subhan, Ihsan Ullah, Muhammad Shahid, Gowhar Ali and Robert D. E. Sewell

    BMC Pharmacology and Toxicology 2017 18:4

    Published on: 13 January 2017

    The Erratum to this article has been published in BMC Pharmacology and Toxicology 2017 18:9

  6. Research article

    Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells

    Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases.

    Victor Kuete, Leonidah K. Omosa, Viviane R. Sipowo Tala, Jacob O. Midiwo, Armelle T. Mbaveng, Sauda Swaleh, Oğuzhan Karaosmanoğlu and Hülya Sivas

    BMC Pharmacology and Toxicology 2016 17:60

    Published on: 21 December 2016

  7. Research article

    Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat

    Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was develop...

    Mohammad Alsalem, Paul Millns, Ahmad Altarifi, Khalid El-Salem, Victoria Chapman and David A. Kendall

    BMC Pharmacology and Toxicology 2016 17:31

    Published on: 21 July 2016

  8. Research article

    Functional and molecular evidence for heteromeric association of P2Y1 receptor with P2Y2 and P2Y4 receptors in mouse granulocytes

    All hematopoietic cells express P2 receptors, however pharmacological characteristics such as expression and affinity in granulocytes are unknown.

    Antonio Carlos Ribeiro-Filho, Marcus Vinicius Buri, Carlos Castilho Barros, Juliana Luporini Dreyfuss, Helena Bonciani Nader, Giselle Zenker Justo, Rogério Bastos Craveiro, João Bosco Pesquero, Antonio Miranda, Alice Teixeira Ferreira and Edgar Julian Paredes-Gamero

    BMC Pharmacology and Toxicology 2016 17:29

    Published on: 7 July 2016

  9. Research article

    Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells

    Previously, we have demonstrated that human ABCB5 is a full-sized ATP-binding cassette transporter that shares strong homology with ABCB1/P-glycoprotein. ABCB5-transfected cells showed resistance to taxanes and a...

    Shingo Kondo, Keita Hongama, Kengo Hanaya, Ryota Yoshida, Takaaki Kawanobe, Kazuhiro Katayama, Kohji Noguchi and Yoshikazu Sugimoto

    BMC Pharmacology and Toxicology 2015 16:37

    Published on: 15 December 2015

  10. Research article

    Cardiac thromboxane A2 receptor activation does not directly induce cardiomyocyte hypertrophy but does cause cell death that is prevented with gentamicin and 2-APB

    We have previously shown that the thromboxane (TXA2) receptor agonist, U46619, can directly induce ventricular arrhythmias that were associated with increases in intracellular calcium in cardiomyocytes. Since ...

    Chad D Touchberry, Neerupma Silswal, Vladimir Tchikrizov, Christopher J Elmore, Shubra Srinivas, Adil S Akthar, Hannah K Swan, Lori A Wetmore and Michael J Wacker

    BMC Pharmacology and Toxicology 2014 15:73

    Published on: 17 December 2014

  11. Research article

    Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

    The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme wi...

    Nicola Laurieri, Akane Kawamura, Isaac M Westwood, Amy Varney, Elizabeth Morris, Angela J Russell, Lesley A Stanley and Edith Sim

    BMC Pharmacology and Toxicology 2014 15:68

    Published on: 29 November 2014

  12. Research article

    Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide

    Lung cancer is characterized by a high mortality rate probably attributable to early metastasis. Oxidative stress is involved in development and progression of lung cancer, through cellular and molecular mecha...

    Luca Gallelli, Daniela Falcone, Monica Scaramuzzino, Girolamo Pelaia, Bruno D’Agostino, Maria Mesuraca, Rosa Terracciano, Giuseppe Spaziano, Rosario Maselli, Michele Navarra and Rocco Savino

    BMC Pharmacology and Toxicology 2014 15:67

    Published on: 29 November 2014

  13. Research article

    Nobiletin suppresses cell viability through AKT Pathways in PC-3 and DU-145 prostate cancer cells

    Nobiletin is a non-toxic dietary flavonoid that possesses anti-cancer properties. Nobiletin has been reported to reduce the risk of prostate cancer, but the mechanism is not well understood. In this study, we ...

    Jianchu Chen, Ashley Creed, Allen Y Chen, Haizhi Huang, Zhaoliang Li, Gary O Rankin, Xingqian Ye, Guihua Xu and Yi Charlie Chen

    BMC Pharmacology and Toxicology 2014 15:59

    Published on: 24 October 2014

  14. Research article

    A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits

    11ß–hydroxysteroid dehydrogenase type1 (11β-HSD1) converts inactive glucocorticoids to active glucocorticoids which, in excess, leads to development of the various risk factors of the metabolic syndrome. Recen...

    Tharappel M Anil, Anilkumar Dandu, KrishnaReddy Harsha, Jaideep Singh, Nitya Shree, Venkatesh Satish Kumar, Mudigere N Lakshmi, Venkategowda Sunil, Chandrashekaran Harish, Gundalmandikal V Balamurali, Baisani S Naveen Kumar, Aralakuppe S Gopala, Shivakumar Pratibha, ManojKumar Sadasivuni, Mammen O Anup, Yoganand Moolemath…

    BMC Pharmacology and Toxicology 2014 15:43

    Published on: 7 August 2014

  15. Research article

    Pharmacological doses of niacin stimulate the expression of genes involved in carnitine uptake and biosynthesis and improve the carnitine status of obese Zucker rats

    Activation of peroxisome proliferator-activated receptor (PPAR)α and PPARδ causes an elevation of tissue carnitine concentrations through induction of genes involved in carnitine uptake [novel organic cation t...

    Aline Couturier, Robert Ringseis, Erika Most and Klaus Eder

    BMC Pharmacology and Toxicology 2014 15:37

    Published on: 9 July 2014

  16. Research article

    Transcriptional regulation of kinases downstream of the T cell receptor: another immunomodulatory mechanism of glucocorticoids

    Glucocorticoids affect peripheral immune responses, including modulation of T-cell activation, differentiation, and apoptosis. The quantity and quality of T-cell receptor (TCR)-triggered intracellular signals ...

    Maria Grazia Petrillo, Katia Fettucciari, Paolo Montuschi, Simona Ronchetti, Luigi Cari, Graziella Migliorati, Emanuela Mazzon, Oxana Bereshchenko, Stefano Bruscoli, Giuseppe Nocentini and Carlo Riccardi

    BMC Pharmacology and Toxicology 2014 15:35

    Published on: 3 July 2014

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