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  1. Research article

    Mechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes

    Sodium-glucose cotransporter 2 (SGLT2) inhibitors are reported to have BP-lowering effect in addition to blood glucose-lowering effect, however, its mechanism is still unknown. This study aimed to investigate ...

    Shin Kawasoe, Yukiko Maruguchi, Shoko Kajiya, Hitoshi Uenomachi, Masaaki Miyata, Mariko Kawasoe, Takuro Kubozono and Mitsuru Ohishi

    BMC Pharmacology and Toxicology 2017 18:23

    Published on: 10 April 2017

  2. Research article

    Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease

    Genetic variation of matrix metalloproteinase 9 (MMP-9) gene polymorphism has been suggested to modulate coronary heart diseases (CHD), yet the underlying mechanisms are not well understood.

    Yuanyuan Xu, Yan Wang, Jixin Zhi, Lichun Qi, Tong Zhang and Xueqi Li

    BMC Pharmacology and Toxicology 2017 18:28

    Published on: 8 April 2017

  3. Research article

    Drug adherence for antihypertensive medications and its determinants among adult hypertensive patients attending in chronic clinics of referral hospitals in Northwest Ethiopia

    Adherence to prescribed medication is an imperative issue which can be directly linked with the management of chronic diseases like hypertension; failure to adhere can affect the effectiveness of medication as...

    Habtamu Sewunet Mekonnen, Mignote Hailu Gebrie, Kokeb Haile Eyasu and Abebaw Addis Gelagay

    BMC Pharmacology and Toxicology 2017 18:27

    Published on: 5 April 2017

  4. Research article

    Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

    Cs2K4Na [SiW9Nb3O40] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rat...

    Xiaofeng Qu, Kun Xu, Chao Zhao, Xiuling Song, Jinhua Li, Li Li, Wei Nie, Hao Bao, Juan Wang, Fenglan Niu and Juan Li

    BMC Pharmacology and Toxicology 2017 18:26

    Published on: 5 April 2017

  5. Research article

    Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis

    Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treat...

    Michelle H. Gurel, Yi Han, Andrea L. Stevens, Aaron Furtado and David Cox

    BMC Pharmacology and Toxicology 2017 18:22

    Published on: 4 April 2017

  6. Research article

    Pharmacokinetics of surotomycin from phase 1 single and multiple ascending dose studies in healthy volunteers

    Surotomycin, a novel, orally administered, cyclic, lipopeptide antibacterial in development for the treatment of Clostridium difficile-associated diarrhea, has demonstrated minimal intestinal absorption in animal...

    Gurudatt Chandorkar, Qiao Zhan, Julie Donovan, Shruta Rege and Hernando Patino

    BMC Pharmacology and Toxicology 2017 18:24

    Published on: 28 March 2017

  7. Case report

    Methimazole associated eosinophilic pleural effusion: a case report

    Adverse reactions associated to anti-thyroid drugs include fever, rash, arthralgia, agranulocytosis and hepatitis that are thought to be hypersensitivity reactions. Five cases of pleural effusion associated to...

    Pedro Gaspar-da-Costa, Filipa Duarte Silva, Júlia Henriques, Sónia do Vale, Sandra Braz, João Meneses Santos and Rui M.M. Victorino

    BMC Pharmacology and Toxicology 2017 18:16

    Published on: 21 March 2017

  8. Research article

    Long-term treatment of clarithromycin at a low concentration improves hydrogen peroxide-induced oxidant/antioxidant imbalance in human small airway epithelial cells by increasing Nrf2 mRNA expression

    Clarithromycin (CAM), a representative macrolide antibiotic, has been used widely at low doses for long-term therapy of chronic inflammatory airway diseases. Anti-inflammatory effects of macrolide antibiotics ...

    Kuninori Iwayama, Ayuko Kusakabe, Keisuke Ohtsu, Takahiro Nawano, Ryosuke Tatsunami, Ko-ichi Ohtaki, Yoshiko Tampo and Nobumasa Hayase

    BMC Pharmacology and Toxicology 2017 18:15

    Published on: 25 February 2017

  9. Research article

    Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460

    Side-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (N...

    Seon Young Choi, Hang-Rae Kim, Pan Dong Ryu and So Yeong Lee

    BMC Pharmacology and Toxicology 2017 18:14

    Published on: 21 February 2017

  10. Research article

    Antibiotic use practices of pharmacy staff: a cross-sectional study in Saint Petersburg, the Russian Federation

    Non-prescription access to antimicrobials is common, and self-prescribing is increasingly popular in Russian society. The aim of this study was to assess the attitudes of community pharmacists regarding antibi...

    Tatiana Belkina, Natalia Duvanova, Julia Karbovskaja, Jurjen Duintjer Tebbens and Jiri Vlcek

    BMC Pharmacology and Toxicology 2017 18:11

    Published on: 14 February 2017

  11. Case report

    A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring

    Invasive aspergillosis (IA) is a fatal infectious complication among immunocompromised patients. Aspergillus terreus, the fourth common species can be difficult to treat due to a unique resistance pattern. To dat...

    Pitchaya Dilokpattanamongkol, Panadda Panusitthikorn, Rasda Boonprasert, Methee Chayakulkeeree and Porpon Rotjanapan

    BMC Pharmacology and Toxicology 2017 18:8

    Published on: 31 January 2017

  12. Research article

    5-aminolevulinic acid combined with ferrous ion reduces adiposity and improves glucose tolerance in diet-induced obese mice via enhancing mitochondrial function

    Mitochondrial dysfunction is associated with obesity and various obesity-associated pathological conditions including glucose intolerance. 5-Aminolevulinic acid (ALA), a precursor of heme metabolites, is a nat...

    Urara Ota, Takeshi Hara, Hitoshi Nakagawa, Emi Tsuru, Masayuki Tsuda, Atsuko Kamiya, Yasushi Kuroda, Yuya Kitajima, Aya Koda, Masahiro Ishizuka, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Motowo Nakajima and Tohru Tanaka

    BMC Pharmacology and Toxicology 2017 18:7

    Published on: 30 January 2017

  13. Case report

    Amitraz poisoning: A case report of an unusual pesticide poisoning in Sri Lanka and literature review

    Amitraz is a pesticide used worldwide on animals and in agriculture. It contains triazapentadiene, which is a centrally acting alpha-2 adrenergic agonist. Amitraz poisoning is fairly uncommon in humans and occ...

    H. M. M. T. B. Herath, S. P. Pahalagamage, Nilukshana Yogendranathan, M. D. M. S. Wijayabandara and Aruna Kulatunga

    BMC Pharmacology and Toxicology 2017 18:6

    Published on: 23 January 2017

  14. Technical advance

    Identification and application of anti-inflammatory compounds screening system based on RAW264.7 cells stably expressing NF-κB-dependent SEAP reporter gene

    NF-κB is one of the key transcription factors in the inflammatory response, transactivates a series of pro-inflammatory genes and is therefore regarded as an important target for anti-inflammatory drug screening.

    Yue Li, Xiaomeng Wang, Juan Ren, Xi Lan, Jing Li, Jing Yi, Li Liu, Yan Han, Sanqi Zhang, Dongmin Li and Shemin Lu

    BMC Pharmacology and Toxicology 2017 18:5

    Published on: 18 January 2017

  15. Research article

    Synthetic and natural antioxidants attenuate cisplatin-induced vomiting

    Synthetic and natural antioxidants including Bacopa monnieri (L.) Pennell (Scrophulariaceae) which also possess anti-dopaminergic properties, have been proposed to be useful for emetogenic chemotherapy. In this s...

    Javaid Alam, Fazal Subhan, Ihsan Ullah, Muhammad Shahid, Gowhar Ali and Robert D. E. Sewell

    BMC Pharmacology and Toxicology 2017 18:4

    Published on: 13 January 2017

    The Erratum to this article has been published in BMC Pharmacology and Toxicology 2017 18:9

  16. Research article

    Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease

    Kawasaki disease (KD) is an acute febrile vasculitis in childhood, which is the leading cause of acquired heart disease in children. If untreated, KD can result in coronary aneurysms in 25% of patients, and ev...

    Fu-Chen Huang, Ho-Chang Kuo, Ying-Hsien Huang, Hong-Ren Yu, Sung-Chou Li and Hsing-Chun Kuo

    BMC Pharmacology and Toxicology 2017 18:3

    Published on: 9 January 2017

  17. Research article

    The efficacy and safety of co-administration of fimasartan and rosuvastatin to patients with hypertension and dyslipidemia

    Hypertension and dyslipidemia are major risk factors of cardiovascular disease (CVD) events. The objective of this study was to evaluate the efficacy and safety of the co-administration of fimasartan and rosuv...

    Moo-Yong Rhee, Taehoon Ahn, Kiyuk Chang, Shung Chull Chae, Tae-Hyun Yang, Wan Joo Shim, Tae Soo Kang, Jae-Kean Ryu, Deuk-Young Nah, Tae-Ho Park, In-Ho Chae, Seung Woo Park, Hae-Young Lee, Seung-Jea Tahk, Young Won Yoon, Chi Young Shim…

    BMC Pharmacology and Toxicology 2017 18:2

    Published on: 5 January 2017

  18. Research article

    Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells

    Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases.

    Victor Kuete, Leonidah K. Omosa, Viviane R. Sipowo Tala, Jacob O. Midiwo, Armelle T. Mbaveng, Sauda Swaleh, Oğuzhan Karaosmanoğlu and Hülya Sivas

    BMC Pharmacology and Toxicology 2016 17:60

    Published on: 21 December 2016

  19. Research article

    Effects on and transfer across the blood-brain barrier in vitro—Comparison of organic and inorganic mercury species

    Transport of methylmercury (MeHg) across the blood-brain barrier towards the brain side is well discussed in literature, while ethylmercury (EtHg) and inorganic mercury are not adequately characterized regardi...

    Hanna Lohren, Julia Bornhorst, Romy Fitkau, Gabriele Pohl, Hans-Joachim Galla and Tanja Schwerdtle

    BMC Pharmacology and Toxicology 2016 17:63

    Published on: 15 December 2016

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