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  1. Research article

    Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease

    Kawasaki disease (KD) is an acute febrile vasculitis in childhood, which is the leading cause of acquired heart disease in children. If untreated, KD can result in coronary aneurysms in 25% of patients, and ev...

    Fu-Chen Huang, Ho-Chang Kuo, Ying-Hsien Huang, Hong-Ren Yu, Sung-Chou Li and Hsing-Chun Kuo

    BMC Pharmacology and Toxicology 2017 18:3

    Published on: 9 January 2017

  2. Research article

    The efficacy and safety of co-administration of fimasartan and rosuvastatin to patients with hypertension and dyslipidemia

    Hypertension and dyslipidemia are major risk factors of cardiovascular disease (CVD) events. The objective of this study was to evaluate the efficacy and safety of the co-administration of fimasartan and rosuv...

    Moo-Yong Rhee, Taehoon Ahn, Kiyuk Chang, Shung Chull Chae, Tae-Hyun Yang, Wan Joo Shim, Tae Soo Kang, Jae-Kean Ryu, Deuk-Young Nah, Tae-Ho Park, In-Ho Chae, Seung Woo Park, Hae-Young Lee, Seung-Jea Tahk, Young Won Yoon, Chi Young Shim…

    BMC Pharmacology and Toxicology 2017 18:2

    Published on: 5 January 2017

  3. Research article

    Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells

    Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases.

    Victor Kuete, Leonidah K. Omosa, Viviane R. Sipowo Tala, Jacob O. Midiwo, Armelle T. Mbaveng, Sauda Swaleh, Oğuzhan Karaosmanoğlu and Hülya Sivas

    BMC Pharmacology and Toxicology 2016 17:60

    Published on: 21 December 2016

  4. Research article

    Effects on and transfer across the blood-brain barrier in vitro—Comparison of organic and inorganic mercury species

    Transport of methylmercury (MeHg) across the blood-brain barrier towards the brain side is well discussed in literature, while ethylmercury (EtHg) and inorganic mercury are not adequately characterized regardi...

    Hanna Lohren, Julia Bornhorst, Romy Fitkau, Gabriele Pohl, Hans-Joachim Galla and Tanja Schwerdtle

    BMC Pharmacology and Toxicology 2016 17:63

    Published on: 15 December 2016

  5. Research article

    Pharmacokinetic and pharmacodynamic characterization of a novel formulation containing co-formulated interferons alpha-2b and gamma in healthy male volunteers

    More potent antitumor activity is desired in Interferon (IFN)-treated cancer patients. This could be achieved by combining IFN alpha and IFN gamma. The aim of this work was to characterize the pharmacokinetics...

    Idrian García-García, Ignacio Hernández-González, Alina Díaz-Machado, Carlos A. González-Delgado, Sonia Pérez-Rodríguez, Yanelda García-Vega, Rosario Campos-Mojena, Ángela D. Tuero-Iglesias, Carmen M. Valenzuela-Silva, Alieski Cruz-Ramírez, Alis Martín-Trujillo, Héctor Santana-Milián, Pedro A. López-Saura and Iraldo Bello-Rivero

    BMC Pharmacology and Toxicology 2016 17:58

    Published on: 7 December 2016

  6. Research article

    Vancomycin microspheres reduce postoperative spine infection in an in vivo rabbit model

    Surgical site infections are common and devastating complications after implants related surgeries. Staphylococcus aureus contamination is a leading cause of surgical site infections. This study aims at assessing...

    Gang Liu, Si Chen, Jun Fang, Baoshan Xu, Shuang Li, Yonghong Hao, Naif A. Al-Dhabi, Shucai Deng and Veeramuthu Duraipandiyan

    BMC Pharmacology and Toxicology 2016 17:61

    Published on: 29 November 2016

  7. Research article

    Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin

    The antimalarial activity of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a naturally occurring naphthoquinone widely distributed in the Plumbaginaceae family has previously been demonstrated in vitro (g...

    Wiriyaporn Sumsakul, Tullayakorn Plengsuriyakarn and Kesara Na-Bangchang

    BMC Pharmacology and Toxicology 2016 17:50

    Published on: 14 November 2016

  8. Research article

    National study on the adequacy of antidotes stocking in Lebanese hospitals providing emergency care

    Antidotes stocking is a critical component of hospital care for poisoned patients in emergency. Antidote stocking represents a major health challenge worldwide and in Lebanon. Systematic data monitoring of ant...

    Anthony Mansour, Layla Al-Bizri, Jad El-Maamary, Amanda al-Helou, Rayan Hamade, Elie Saliba, Dina Khammash, Karim Makhoul, Kamal Matli, Nada Ghosn, Mary Deeb and Wissam H. Faour

    BMC Pharmacology and Toxicology 2016 17:51

    Published on: 7 November 2016

  9. Editorial

    A greater focus on metals in biomedicine and neuroscience is needed

    Metals have many essential functions in the brain and a large body of evidence supports important roles for altered metal stasis in many brain disorders. However, despite this evidence, acceptance of metals as...

    Anthony R. White

    BMC Pharmacology and Toxicology 2016 17:53

    Published on: 5 November 2016

  10. Review

    “Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”

    Manganese (Mn) is an essential heavy metal. However, Mn’s nutritional aspects are paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we covered recent advances in identifying me...

    Tanara V. Peres, Maria Rosa C. Schettinger, Pan Chen, Fabiano Carvalho, Daiana S. Avila, Aaron B. Bowman and Michael Aschner

    BMC Pharmacology and Toxicology 2016 17:57

    Published on: 4 November 2016

  11. Research article

    Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans

    All living cells display a rapid molecular response to adverse environmental conditions, and the heat shock protein family reflects one such example. Hence, failing to activate heat shock proteins can impair t...

    Daiana Silva Avila, Alexandre Benedetto, Catherine Au, Julia Bornhorst and Michael Aschner

    BMC Pharmacology and Toxicology 2016 17:54

    Published on: 2 November 2016

  12. Research article

    Chronic early life lead (Pb2+) exposure alters presynaptic vesicle pools in hippocampal synapses

    Lead (Pb2+) exposure has been shown to impair presynaptic neurotransmitter release in both in vivo and in vitro model systems. The mechanism by which Pb2+ impairs neurotransmitter release has not been fully eluci...

    Sara Rose Guariglia, Kirstie H. Stansfield, Jennifer McGlothan and Tomas R. Guilarte

    BMC Pharmacology and Toxicology 2016 17:56

    Published on: 2 November 2016

  13. Research article

    Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice

    Metallothioneins (MT) are small proteins, which are crucial for the distribution of heavy and transition metals. Previously, we found in mice that knockout of MT 1 and 2 genes (MTKO) impaired spatial learning ...

    Ann Petro, Hannah G. Sexton, Caroline Miranda, Anit Rastogi, Jonathan H. Freedman and Edward D. Levin

    BMC Pharmacology and Toxicology 2016 17:55

    Published on: 2 November 2016

  14. Research article

    Quality of Artemisinin-based Combination Therapy for malaria found in Ghanaian markets and public health implications of their use

    Ghana changed their antimalarial drug policy from monotherapies to Artemisinin-based Combination Therapies in 2004 in order to provide more efficacious medicines for treatment of malaria. The policy change can...

    Mathilda Tivura, Isaac Asante, Albert van Wyk, Stephaney Gyaase, Naiela Malik, Emmanuel Mahama, Dana M. Hostetler, Facundo M. Fernandez, Kwaku Poku Asante, Harparkash Kaur and Seth Owusu-Agyei

    BMC Pharmacology and Toxicology 2016 17:48

    Published on: 28 October 2016

  15. Research article

    Side effect profile similarities shared between antidepressants and immune-modulators reveal potential novel targets for treating major depressive disorders

    Side effects, or the adverse effects of drugs, contain important clinical phenotypic information that may be useful in predicting novel or unknown targets of a drug. It has been suggested that drugs with simil...

    Yu Sun, Vaibhav A. Narayan and Gayle M. Wittenberg

    BMC Pharmacology and Toxicology 2016 17:47

    Published on: 21 October 2016

  16. Research article

    Study of arsenic accumulation in rice and evaluation of protective effects of Chorchorus olitorius leaves against arsenic contaminated rice induced toxicities in Wistar albino rats

    In the present study, we investigated the arsenic accumulation in different parts of rice irrigated with arsenic contaminated water. Besides, we also evaluated the protective effects of Corchorus olitorius leaves...

    Saeed Mohammed Imran Hosen, Dipesh Das, Rupkanowar Kobi, Dil Umme Salma Chowdhury, Md Jibran Alam, Bashudev Rudra, Muhammad Abu Bakar, Saiful Islam, Zillur Rahman and Mohammad Al-Forkan

    BMC Pharmacology and Toxicology 2016 17:46

    Published on: 14 October 2016

  17. Research article

    Current statins show calcium channel blocking activity through voltage gated channels

    Statins are used for treatment of hypercholestremia. Common adverse reports associated with use of statins are generalized bodyache, rhabdomyolysis, muscles weakness and gastrointestinal disorders. The current...

    Niaz Ali, Robina Begum, Muhammad Saleh Faisal, Aslam Khan, Muhammad Nabi, Gulfam Shehzadi, Shakir Ullah and Waqar Ali

    BMC Pharmacology and Toxicology 2016 17:43

    Published on: 21 September 2016

  18. Research article

    Dependence to legally prescribed opioid analgesics in a university hospital in Medellin-Colombia: an observational study

    In some countries the misuse and diversion of prescribed opioid analgesic is increasing considerably, but there is no official data regarding the situation in Colombia. The aim of this study was to identify al...

    Maria G. Garcia-Orjuela, Lineth Alarcon-Franco, Juan C. Sanchez-Fernandez, Yuli Agudelo and Andres F. Zuluaga

    BMC Pharmacology and Toxicology 2016 17:42

    Published on: 14 September 2016

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