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  1. Research article

    The albumin-exendin-4 recombinant protein E2HSA improves glycemic control and β-cell function in spontaneous diabetic KKAy mice

    E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2H...

    Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu and Zhufang Shen

    BMC Pharmacology and Toxicology 2017 18:48

    Published on: 19 June 2017

  2. Research article

    Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway

    The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the...

    Mariam A. Ba, Jeffrey Surina, Cherie A. Singer and Maria L. Valencik

    BMC Pharmacology and Toxicology 2017 18:47

    Published on: 17 June 2017

  3. Research article

    Profound perturbation induced by triclosan exposure in mouse gut microbiome: a less resilient microbial community with elevated antibiotic and metal resistomes

    Environmental chemical-induced perturbations of gut microbiome are associated with a series of adverse health outcomes. The effects of triclosan on human health have been controversial in recent years. The pur...

    Bei Gao, Pengcheng Tu, Xiaoming Bian, Liang Chi, Hongyu Ru and Kun Lu

    BMC Pharmacology and Toxicology 2017 18:46

    Published on: 12 June 2017

  4. Research article

    Pain sensitivity and analgesic use among 10,486 adults: the Tromsø study

    Increased pain sensitivity is a putative risk factor for chronic pain and consequently for analgesic use. Conversely, analgesic use may be a cause of increased pain sensitivity, e.g., through opioid-induced hy...

    Per-Jostein Samuelsen, Christopher Sivert Nielsen, Tom Wilsgaard, Audun Stubhaug, Kristian Svendsen and Anne Elise Eggen

    BMC Pharmacology and Toxicology 2017 18:45

    Published on: 9 June 2017

  5. Research article

    Data-driven prediction of adverse drug reactions induced by drug-drug interactions

    The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-de...

    Ruifeng Liu, Mohamed Diwan M. AbdulHameed, Kamal Kumar, Xueping Yu, Anders Wallqvist and Jaques Reifman

    BMC Pharmacology and Toxicology 2017 18:44

    Published on: 8 June 2017

  6. Case report

    Tardive akathisia related to the anti-hypertensive agent Sevikar-a case report

    Tardive akathisia (TA) is a subtype of tardive syndrome, and its etiology is still uncertain. Sevikar is an anti-hypertensive agent containing both amlodipine and olmesartan, and has never been reported to hav...

    Men-Ting Hsieh, Pao-Yen Lin, Chia-Jen Tsai, Chiung-Chih Chang and Yu Lee

    BMC Pharmacology and Toxicology 2017 18:41

    Published on: 5 June 2017

  7. Research article

    Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity

    Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional stud...

    Dina Popova, Jessica Karlsson and Stig O. P. Jacobsson

    BMC Pharmacology and Toxicology 2017 18:42

    Published on: 5 June 2017

  8. Research article

    Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads

    Protein ubiquitylation is an important post-translational regulation, which has been shown to be necessary for life cycle progression and survival of Plasmodium falciparum. Ubiquitin is a highly conserved 76 amin...

    Jagrati Jain, Surendra K. Jain, Larry A. Walker and Babu L. Tekwani

    BMC Pharmacology and Toxicology 2017 18:40

    Published on: 2 June 2017

  9. Research article

    Hesperetin-5,7,3’-O-triacetate suppresses airway hyperresponsiveness in ovalbumin-sensitized and challenged mice without reversing xylazine/ketamine-induced anesthesia in normal mice

    We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma ...

    You-Lan Yang, Chi-Li Chen, Chi-Ming Chen and Wun-Chang Ko

    BMC Pharmacology and Toxicology 2017 18:39

    Published on: 30 May 2017

  10. Case report

    A case report of zinc phosphide poisoning: complicated by acute renal failure and tubulo interstitial nephritis

    Run Rat® is a rodenticide widely used against small mammals. It comprises of a minimum of 32% zinc phosphide which is highly toxic in acute exposures to humans. It may be consumed accidentally or intentionally...

    Nilukshana Yogendranathan, H. M. M. T. B. Herath, Thenuka Sivasundaram, R. Constantine and Aruna Kulatunga

    BMC Pharmacology and Toxicology 2017 18:37

    Published on: 25 May 2017

  11. Research article

    Psychotropic drug use and mortality in old people with dementia: investigating sex differences

    Psychotropic drugs are common among old people with dementia, and have been associated with increased mortality. Previous studies have not investigated sex differences in this risk. This study was conducted to...

    Jon Brännström, Gustaf Boström, Erik Rosendahl, Peter Nordström, Håkan Littbrand, Hugo Lövheim and Yngve Gustafson

    BMC Pharmacology and Toxicology 2017 18:36

    Published on: 25 May 2017

  12. Research article

    Antimicrobial resistance profile of Staphylococcus aureus isolates isolated from ear discharges of patients at University of Hawassa comprehensive specialized hospital

    Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a ...

    Serawit Deyno, Alemayehu Toma, Mesfin Worku and Muluken Bekele

    BMC Pharmacology and Toxicology 2017 18:35

    Published on: 15 May 2017

  13. Research article

    The salvage therapy in lung adenocarcinoma initially harbored susceptible EGFR mutation and acquired resistance occurred to the first-line gefitinib and second-line cytotoxic chemotherapy

    Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib can provide better efficacy and prolonged progression free survival (PFS) than cytotoxic chemotherapy for metastatic lung ...

    Chih-Jen Yang, Jen-Yu Hung, Ming-Ju Tsai, Kuan-Li Wu, Ta-Chih Liu, Shah-Hwa Chou, Jui-Ying Lee, Jui-Sheng Hsu, Ming-Shyan Huang and Inn-Wen Chong

    BMC Pharmacology and Toxicology 2017 18:21

    Published on: 10 May 2017

  14. Research article

    Effects of diacetyl-liensinine on electrophysiology in rabbit ventricular myocytes

    Diacetyl-liensinine is a chemosynthetic derivative of liensinine, extracted from the seed embryo of Nelumbo nucifera Gaertn, in China. It has been found to have extensive anti- arrhythmic actions. The present stu...

    Feng Cao, Teng Wang, Wenmao Ding, Zhe Li, Shaobo Shi and Xiaozhan Wang

    BMC Pharmacology and Toxicology 2017 18:33

    Published on: 5 May 2017

  15. Research article

    Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line

    Cardol is a major bioactive constituent in the Trigona incisa propolis from Indonesia, with a strong in vitro antiproliferative activity against the SW620 colorectal adenocarcinoma cell line (IC50 of 4.51 ± 0.76 ...

    Paula Mariana Kustiawan, Kriengsak Lirdprapamongkol, Tanapat Palaga, Songchan Puthong, Preecha Phuwapraisirisan, Jisnuson Svasti and Chanpen Chanchao

    BMC Pharmacology and Toxicology 2017 18:32

    Published on: 4 May 2017

  16. Research article

    Erroneous formulation of delayed-release omeprazole capsules: alert for importing countries

    Poor drug quality is a matter of serious concern, especially in countries where drug regulation and law enforcement are constrained by limited resources. This study was carried out to investigate the cause of ...

    Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, Tep Keila, Tey Sovannarith, Heng Bun Kiet, Eav Dararth, Theingi Zin, Tsuyoshi Tanimoto and Kazuko Kimura

    BMC Pharmacology and Toxicology 2017 18:31

    Published on: 3 May 2017

  17. Research article

    Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects

    Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to...

    Matthieu Chartier, Louis-Philippe Morency, María Inés Zylber and Rafael J. Najmanovich

    BMC Pharmacology and Toxicology 2017 18:18

    Published on: 28 April 2017

  18. Research article

    Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells

    Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patie...

    Yu-Guang Ma, Jun-Wei Wang, Yun-Gang Bai, Mei Liu, Man-Jiang Xie and Zhi-Jun Dai

    BMC Pharmacology and Toxicology 2017 18:30

    Published on: 26 April 2017

  19. Research article

    Dichloroacetic acid-induced testicular toxicity in male rats and the protective effect of date fruit extract

    The present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats.

    Amira El Arem, Lamia Lahouar, Emna Behija Saafi, Amira Thouri, Fatma Ghrairi, Zohra Houas, Fadoua Neffati and Lotfi Achour

    BMC Pharmacology and Toxicology 2017 18:17

    Published on: 22 April 2017

  20. Research article

    Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

    The objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats.

    Anayt Ulla, Mustafe Khalid Mohamed, Biswajit Sikder, AFM Towheedur Rahman, Farzana Akther Sumi, Murad Hossain, Hasan Mahmud Reza, G. M. Sayedur Rahman and Md Ashraful Alam

    BMC Pharmacology and Toxicology 2017 18:29

    Published on: 20 April 2017

  21. Research article

    Adverse drug events observed in patients with type 2 diabetes mellitus treated with 100 mg versus 300 mg canagliflozin: a systematic review and meta-analysis of published randomized controlled trials

    Nowadays, canagliflozin monotherapy, or in combination with other oral hypoglycemic agents (OHAs), is often administered in patients who are treated for type 2 diabetes mellitus (T2DM). Therefore, we aimed to ...

    Pravesh Kumar Bundhun, Girish Janoo and Feng Huang

    BMC Pharmacology and Toxicology 2017 18:19

    Published on: 16 April 2017

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