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Table 3 Individual patient estimates of amikacin pharmacokinetic parameters during CVVHDF therapy assuming a two compartment model

From: An open prospective study of amikacin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration

ID

k (h-1)

V1 (l)

TBC (l h-1)

T1/2α (h)

T1/2β (h)

T1/2el (h)

Vss (l)

P1B

0.093

25.0

2.32

0.25

8.18

7.45

27.33

P2C

0.131

21.95

2.88

0.035

7.61

5.29

31.5

P3C

0.172

24.31

4.19

0.028

5.29

4.02

31.94

  1. t1/2α: half life of the alpha phase. t1/2β: half life of the beta phase. t1/2el: elimination half life. Vss: volume of distribution at steady state. V1: volume of distribution of the central compartment. TBC: Total body clearance. k: elimination rate constant. CV%: coefficient of variation. PX (1–5) patients 1–5.