Patient profile
|
Dose
|
Dosage interval
|
Cpmax
|
Cpmin
|
t1/2
|
k
|
TBC
|
Vd
|
---|
(mg)
|
(h)
|
(mg l-1)
|
(mg l-1)
|
(h)
|
(h-1)
|
(l h-1)
|
(l)
|
---|
P1A
|
900
|
24
|
31.3
|
3
|
6.80
|
0.102
|
2.858
|
28.03
|
P1B
|
900
|
24
|
33.8
|
4
|
7.63
|
0.091
|
2.583
|
28.44
|
P1C
|
1100
|
24
|
35.7
|
6.2
|
9.10
|
0.076
|
2.579
|
33.89
|
Mean
| | | | |
7.84
|
0.090
|
2.674
|
30.12
|
P2A
|
300
|
19
|
7.6
|
1.8
|
8.66
|
0.080
|
3.096
|
38.69
|
P2B
|
1500
|
24
|
50.2
|
2.8
|
5.52
|
0.125
|
3.761
|
29.97
|
P2C
|
1500
|
24
|
48.5
|
5.4
|
7.42
|
0.093
|
2.987
|
31.98
|
P2D
|
1500
|
29
|
49.4
|
5
|
8.47
|
0.082
|
2.719
|
33.24
|
P2E
|
1500
|
32
|
55.9
|
6.1
|
9.70
|
0.071
|
2.062
|
28.85
|
P2F
|
1500
|
29
|
53.8
|
7
|
9.51
|
0.073
|
2.239
|
30.74
|
Mean
| | | | |
8.21
|
0.088
|
2.811
|
32.25
|
CVVHDF Stopped P2G
|
1500
|
53.5
|
68.3
|
16.1
|
25.18
|
0.028
|
0.668
|
24.26
|
P3A
|
1500
|
24
|
44.9
|
2.8
|
5.74
|
0.121
|
3.911
|
32.42
|
P3B
|
1500
|
24
|
42.4
|
1.9
|
5.13
|
0.135
|
4.923
|
36.46
|
P3C
|
1500
|
24
|
46.5
|
2.1
|
5.26
|
0.132
|
4.278
|
32.46
|
Mean
| | | | |
5.38
|
0.129
|
4.371
|
33.78
|
P4A
|
600
|
12
|
16.2
|
4
|
5.45
|
0.127
|
4.563
|
35.88
|
P4B
|
600
|
12
|
23.4
|
5
|
5.16
|
0.134
|
3.961
|
29.52
|
Mean
| | | | |
5.31
|
0.131
|
4.262
|
32.70
|
P5A
|
1500
|
24
|
48.2
|
2.1
|
5.09
|
0.136
|
4.099
|
30.08
|
P5B
|
1500
|
25
|
52.4
|
2.4
|
5.39
|
0.128
|
3.701
|
28.81
|
P5C
|
1500
|
28
|
54.4
|
2.5
|
5.29
|
0.131
|
3.649
|
27.84
|
P5D
|
1500
|
28
|
55.8
|
2.5
|
6.03
|
0.115
|
3.137
|
27.28
|
Mean
| | | | |
5.45
|
0.128
|
3.646
|
28.50
|
Overall mean*
| | | | |
6.74
|
0.109
|
3.39
|
31.4
|
Standard deviation
| | | | |
1.69
|
0.025
|
0.82
|
3.27
|
Median
| | | | |
5.88
|
0.118
|
3.39
|
30.4
|
- * Excluding profile P2G.
- Cpmax: maximum serum concentration Cpmin: minimum serum concentration.
- t1/2: half life. Vd: volume of distribution. TBC: Total body clearance. k: elimination rate constant.
- PX (1–5): patients 1–5. PXA-PXE: first (A) to fifth (E) dosing interval during which serum concentration data was collected for patient PX.