Patient profile | Dose | Dosage interval | Cpmax | Cpmin | t1/2 | k | TBC | Vd |
---|---|---|---|---|---|---|---|---|
(mg) | (h) | (mg l-1) | (mg l-1) | (h) | (h-1) | (l h-1) | (l) | |
P1A | 900 | 24 | 31.3 | 3 | 6.80 | 0.102 | 2.858 | 28.03 |
P1B | 900 | 24 | 33.8 | 4 | 7.63 | 0.091 | 2.583 | 28.44 |
P1C | 1100 | 24 | 35.7 | 6.2 | 9.10 | 0.076 | 2.579 | 33.89 |
Mean | 7.84 | 0.090 | 2.674 | 30.12 | ||||
P2A | 300 | 19 | 7.6 | 1.8 | 8.66 | 0.080 | 3.096 | 38.69 |
P2B | 1500 | 24 | 50.2 | 2.8 | 5.52 | 0.125 | 3.761 | 29.97 |
P2C | 1500 | 24 | 48.5 | 5.4 | 7.42 | 0.093 | 2.987 | 31.98 |
P2D | 1500 | 29 | 49.4 | 5 | 8.47 | 0.082 | 2.719 | 33.24 |
P2E | 1500 | 32 | 55.9 | 6.1 | 9.70 | 0.071 | 2.062 | 28.85 |
P2F | 1500 | 29 | 53.8 | 7 | 9.51 | 0.073 | 2.239 | 30.74 |
Mean | 8.21 | 0.088 | 2.811 | 32.25 | ||||
CVVHDF Stopped P2G | 1500 | 53.5 | 68.3 | 16.1 | 25.18 | 0.028 | 0.668 | 24.26 |
P3A | 1500 | 24 | 44.9 | 2.8 | 5.74 | 0.121 | 3.911 | 32.42 |
P3B | 1500 | 24 | 42.4 | 1.9 | 5.13 | 0.135 | 4.923 | 36.46 |
P3C | 1500 | 24 | 46.5 | 2.1 | 5.26 | 0.132 | 4.278 | 32.46 |
Mean | 5.38 | 0.129 | 4.371 | 33.78 | ||||
P4A | 600 | 12 | 16.2 | 4 | 5.45 | 0.127 | 4.563 | 35.88 |
P4B | 600 | 12 | 23.4 | 5 | 5.16 | 0.134 | 3.961 | 29.52 |
Mean | 5.31 | 0.131 | 4.262 | 32.70 | ||||
P5A | 1500 | 24 | 48.2 | 2.1 | 5.09 | 0.136 | 4.099 | 30.08 |
P5B | 1500 | 25 | 52.4 | 2.4 | 5.39 | 0.128 | 3.701 | 28.81 |
P5C | 1500 | 28 | 54.4 | 2.5 | 5.29 | 0.131 | 3.649 | 27.84 |
P5D | 1500 | 28 | 55.8 | 2.5 | 6.03 | 0.115 | 3.137 | 27.28 |
Mean | 5.45 | 0.128 | 3.646 | 28.50 | ||||
Overall mean* | 6.74 | 0.109 | 3.39 | 31.4 | ||||
Standard deviation | 1.69 | 0.025 | 0.82 | 3.27 | ||||
Median | 5.88 | 0.118 | 3.39 | 30.4 |