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Table 5 Clearance of amikacin and creatinine by CVVHDF and summary of CVVHDF conditions

From: An open prospective study of amikacin pharmacokinetics in critically ill patients during treatment with continuous venovenous haemodiafiltration

Patient profile ClCVVHDF (l h-1) FCVVHDF CrCl (l h-1) Actual effluent flow rate (l h-1) Number. of filters ^ Age of filter* (h)
P1C 2.53 0.98 2.19 3.16 1 16
P2D 2.55 0.94 2.70 2.91 1 27
P3A 3.40 0.87 3.20 4.10 1 1
P5B 2.97 0.80 2.86 3.95 1 26
Mean 2.86 0.90 2.74 3.53 1 -
+/− +/− +/− +/− +/−   
s.d. 0.412 0.08 0.42 0.584   
  1. *At start of dosage interval.
  2. ^ During dosage interval.
  3. PX (1–5) patients 1–5. ClCVVHDF: clearance via CVVHDF FCVVHDF: Fraction of total body clearance via CVVHDF. CrCl: Creatinine clearance.