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Table 1 Characterization of the four ionic currents present in the Tox-Database.net

From: Tox-Database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

Ion Type Current Phase Channel Gene Subunit Mutations and polymorphisms Disorders associated with mutations Source
Na+ Voltage-gated INa
(fast sodium current)
0 Nav1.5 SCN5A alfa H558R, S216L, del AL 586-587, R680H, R1193Q, T1304M, F1486L, V1951L, F2004L P2006A, S1103Y, R190G, A572D - Long QT syndrome type 3 [1325]
- Sudden cardiac death
- Risk Factor for Atrial Fibrillation
- Brugada syndrome
- Idiopathic ventricular fibrillation
- Heart rhythm disorders
- Romano-Ward syndrome
- SIDS (Sudden infant death  syndrome)
Ca 2+ Voltage-gated ICaL (L-type calcium current) 2 CaV1.2 CACNA1C alfa 1 C G406R, G402S - Timothy syndrome [19, 22, 26, 27]
K+ Voltage-gated IKr (rapid delayed rectifier potassium current) 3 Kv11.1 KCNH2 (hERG) alfa P347S, R1047L, A1116V, K897T, P967L, Q1068R, R181Q, G187S, GAG187-189del, A190T, A203T, N257H, T367S, G873S, P910L, R1035W, A1058E, N33T, R176W, V215G, H254Q, C723R, P917L, L1023del, A915V, P251A, G965R, R1055Q, L1108V, G1154S, T875M, R273Q, V279M, R885C, S1040G, G294V, A190T, N588K - Long QT syndrome type 2 [13, 14, 1720, 22, 23, 2837]
- Romano-Ward syndrome
- SIDS
- Short QT syndrome
     MiRP1 KCNE2 beta Q9E, A66V, T8A, R27C - Long QT syndrome type 6 [13, 14, 1720, 22, 23, 25, 28, 31, 33, 36, 38]
- Familial atrial fibrillation
- Romano-Ward syndrome
- SIDS
   IKs
(slow delayed rectifier potassium current)
3 KvLQT1 (Kv7.1) KCNQ1 alfa IAP54-56dup, V129I, V207M, G297S, F335L, P408A, P448R, R451Q, G621S, G643S, V648I, V110I, K393N, D428G, R519H, P441S, G119D, I274V, G460S, V307L, T600M, V648I - Long QT syndrome type 1 [13, 14, 17, 19, 20, 23, 31, 39, 40]
- Atrial fibrillation  
- Jervell and Lange-Nielsen  syndrome
- Romano-Ward  syndrome
 
- SIDS  
     MinK KCNE1 beta G38S, G52A, K69R, D85N, V109I, V14I - Long QT syndrome type 5 [13, 14, 1720, 22, 23, 31, 34, 36, 41]
         - Jervell and Lange-Nielsen syndrome  
         - Romano-Ward syndrome