TY - STD TI - Global Report: UNAIDS report on the global AIDS epidemic 2010.http://www.unaids.org/globalreport/Global_report.htm, UR - http://www.unaids.org/globalreport/Global_report.htm ID - ref1 ER - TY - JOUR AU - Ramjee, G. PY - 2010 DA - 2010// TI - Microbicide research: current and future directions JO - Curr Opin HIV AIDS VL - 5 UR - https://doi.org/10.1097/COH.0b013e32833a9f66 DO - 10.1097/COH.0b013e32833a9f66 ID - Ramjee2010 ER - TY - JOUR AU - Nuttall, J. PY - 2010 DA - 2010// TI - Microbicides in the prevention of HIV infection: current status and future directions JO - Drugs VL - 70 ID - Nuttall2010 ER - TY - JOUR AU - Minces, L. R. AU - McGowan, I. PY - 2010 DA - 2010// TI - Advances in the Development of Microbicides for the Prevention of HIV Infection JO - Curr Infect Dis Rep VL - 12 UR - https://doi.org/10.1007/s11908-009-0076-5 DO - 10.1007/s11908-009-0076-5 ID - Minces2010 ER - TY - JOUR AU - Van Damme, L. AU - Ramjee, G. AU - Alary, M. AU - Vuylsteke, B. AU - Chandeying, V. AU - Rees, H. AU - Sirivongrangson, P. AU - Mukenge-Tshibaka, L. AU - Ettiegne-Traore, V. AU - Uaheowitchai, C. PY - 2002 DA - 2002// TI - Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial JO - Lancet VL - 360 UR - https://doi.org/10.1016/S0140-6736(02)11079-8 DO - 10.1016/S0140-6736(02)11079-8 ID - Van Damme2002 ER - TY - JOUR AU - Peterson, L. AU - Nanda, K. AU - Opoku, B. K. AU - Ampofo, W. K. AU - Owusu-Amoako, M. AU - Boakye, A. Y. AU - Rountree, W. AU - Troxler, A. AU - Dominik, R. AU - Roddy, R. PY - 2007 DA - 2007// TI - SAVVY (C31G) gel for prevention of HIV infection in women: a Phase 3, double-blind, randomized, placebo-controlled trial in Ghana JO - PLoS One VL - 2 UR - https://doi.org/10.1371/journal.pone.0001312 DO - 10.1371/journal.pone.0001312 ID - Peterson2007 ER - TY - JOUR AU - Pirrone, V. AU - Wigdahl, B. AU - Krebs, F. C. PY - 2011 DA - 2011// TI - The rise and fall of polyanionic inhibitors of the human immunodeficiency virus type 1 JO - Antiviral Res VL - 90 UR - https://doi.org/10.1016/j.antiviral.2011.03.176 DO - 10.1016/j.antiviral.2011.03.176 ID - Pirrone2011 ER - TY - JOUR AU - Veazey, R. S. PY - 2008 DA - 2008// TI - Microbicide safety/efficacy studies in animals: macaques and small animal models JO - Curr Opin HIV AIDS VL - 3 UR - https://doi.org/10.1097/COH.0b013e32830891bb DO - 10.1097/COH.0b013e32830891bb ID - Veazey2008 ER - TY - JOUR AU - Hillier, S. L. AU - Moench, T. AU - Shattock, R. AU - Black, R. AU - Reichelderfer, P. AU - Veronese, F. PY - 2005 DA - 2005// TI - In vitro and in vivo: the story of nonoxynol 9 JO - J Acquir Immune Defic Syndr VL - 39 UR - https://doi.org/10.1097/01.qai.0000159671.25950.74 DO - 10.1097/01.qai.0000159671.25950.74 ID - Hillier2005 ER - TY - JOUR AU - Benes, S. AU - McCormack, W. M. PY - 1985 DA - 1985// TI - Inhibition of growth of Chlamydia trachomatis by nonoxynol-9 in vitro JO - Antimicrob Agents Chemother VL - 27 UR - https://doi.org/10.1128/AAC.27.5.724 DO - 10.1128/AAC.27.5.724 ID - Benes1985 ER - TY - JOUR AU - Kelly, J. P. AU - Reynolds, R. B. AU - Stagno, S. AU - Louv, W. C. AU - Alexander, W. J. PY - 1985 DA - 1985// TI - In vitro activity of the spermicide nonoxynol-9 against Chlamydia trachomatis JO - Antimicrob Agents Chemother VL - 27 UR - https://doi.org/10.1128/AAC.27.5.760 DO - 10.1128/AAC.27.5.760 ID - Kelly1985 ER - TY - JOUR AU - Asculai, S. S. AU - Weis, M. T. AU - Rancourt, M. W. AU - Kupferberg, A. B. PY - 1978 DA - 1978// TI - Inactivation of herpes simplex viruses by nonionic surfactants JO - Antimicrob Agents Chemother VL - 13 UR - https://doi.org/10.1128/AAC.13.4.686 DO - 10.1128/AAC.13.4.686 ID - Asculai1978 ER - TY - JOUR AU - Jennings, R. AU - Clegg, A. PY - 1993 DA - 1993// TI - The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro JO - J Antimicrob Chemother VL - 32 UR - https://doi.org/10.1093/jac/32.1.71 DO - 10.1093/jac/32.1.71 ID - Jennings1993 ER - TY - JOUR AU - Malkovsky, M. AU - Newell, A. AU - Dalgleish, A. G. PY - 1988 DA - 1988// TI - Inactivation of HIV by nonoxynol-9 JO - Lancet VL - 1 UR - https://doi.org/10.1016/S0140-6736(88)91440-7 DO - 10.1016/S0140-6736(88)91440-7 ID - Malkovsky1988 ER - TY - JOUR AU - Krebs, F. C. AU - Miller, S. R. AU - Malamud, D. AU - Howett, M. K. AU - Wigdahl, B. PY - 1999 DA - 1999// TI - Inactivation of human immunodeficiency virus type 1 by nonoxynol-9, C31G, or an alkyl sulfate, sodium dodecyl sulfate JO - Antiviral Res VL - 43 UR - https://doi.org/10.1016/S0166-3542(99)00044-3 DO - 10.1016/S0166-3542(99)00044-3 ID - Krebs1999 ER - TY - JOUR AU - Polsky, B. AU - Baron, P. A. AU - Gold, J. W. AU - Smith, J. L. AU - Jensen, R. H. AU - Armstrong, D. PY - 1988 DA - 1988// TI - In vitro inactivation of HIV-1 by contraceptive sponge containing nonoxynol-9 JO - Lancet VL - 1 UR - https://doi.org/10.1016/S0140-6736(88)92261-1 DO - 10.1016/S0140-6736(88)92261-1 ID - Polsky1988 ER - TY - JOUR AU - Singh, B. AU - Cutler, J. C. AU - Utidjian, H. M. PY - 1972 DA - 1972// TI - Studies on development of a vaginal preparation providing both prophylaxis against venereal disease, other genital infections and contraception. 3. In vitro effect of vaginal contraceptive and selected vaginal preparations of Candida albicans and Trichomonas vaginalis JO - Contraception VL - 5 UR - https://doi.org/10.1016/0010-7824(72)90032-7 DO - 10.1016/0010-7824(72)90032-7 ID - Singh1972 ER - TY - JOUR AU - Cook, R. L. AU - Rosenberg, M. J. PY - 1998 DA - 1998// TI - Do spermicides containing nonoxynol-9 prevent sexually transmitted infections? A meta-analysis JO - Sex Transm Dis VL - 25 UR - https://doi.org/10.1097/00007435-199803000-00007 DO - 10.1097/00007435-199803000-00007 ID - Cook1998 ER - TY - JOUR AU - Catalone, B. J. AU - Kish-Catalone, T. M. AU - Budgeon, L. R. AU - Neely, E. B. AU - Ferguson, M. AU - Krebs, F. C. AU - Howett, M. K. AU - Labib, M. AU - Rando, R. AU - Wigdahl, B. PY - 2004 DA - 2004// TI - Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides JO - Antimicrob Agents Chemother VL - 48 UR - https://doi.org/10.1128/AAC.48.5.1837-1847.2004 DO - 10.1128/AAC.48.5.1837-1847.2004 ID - Catalone2004 ER - TY - JOUR AU - Roddy, R. E. AU - Cordero, M. AU - Cordero, C. AU - Fortney, J. A. PY - 1993 DA - 1993// TI - A dosing study of nonoxynol-9 and genital irritation JO - Int J STD AIDS VL - 4 ID - Roddy1993 ER - TY - JOUR AU - Chvapil, M. AU - Droegemueller, W. AU - Owen, J. A. AU - Eskelson, C. D. AU - Betts, K. PY - 1980 DA - 1980// TI - tudies of nonoxynol-9. I. The effect on the vaginas of rabbits and rats JO - Fertil Steril VL - 33 UR - https://doi.org/10.1016/S0015-0282(16)44665-0 DO - 10.1016/S0015-0282(16)44665-0 ID - Chvapil1980 ER - TY - JOUR AU - Kaminsky, M. AU - Szivos, M. M. AU - Brown, K. R. AU - Willigan, D. A. PY - 1985 DA - 1985// TI - Comparison of the sensitivity of the vaginal mucous membranes of the albino rabbit and laboratory rat to nonoxynol-9 JO - Food Chem Toxicol VL - 23 UR - https://doi.org/10.1016/0278-6915(85)90161-9 DO - 10.1016/0278-6915(85)90161-9 ID - Kaminsky1985 ER - TY - JOUR AU - Catalone, B. J. AU - Ferguson, M. L. AU - Miller, S. R. AU - Malamud, D. AU - Kish-Catalone, T. AU - Thakkar, N. J. AU - Krebs, F. C. AU - Howett, M. K. AU - Wigdahl, B. PY - 2005 DA - 2005// TI - Prolonged exposure to the candidate microbicide C31G differentially reduces cellular sensitivity to agent re-exposure JO - Biomed Pharmacother VL - 59 UR - https://doi.org/10.1016/j.biopha.2005.07.009 DO - 10.1016/j.biopha.2005.07.009 ID - Catalone2005 ER - TY - JOUR AU - Catalone, B. J. AU - Miller, S. R. AU - Ferguson, M. L. AU - Malamud, D. AU - Kish-Catalone, T. AU - Thakkar, N. J. AU - Krebs, F. C. AU - Howett, M. K. AU - Wigdahl, B. PY - 2005 DA - 2005// TI - Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G JO - Biomed Pharmacother VL - 59 UR - https://doi.org/10.1016/j.biopha.2005.07.008 DO - 10.1016/j.biopha.2005.07.008 ID - Catalone2005 ER - TY - JOUR AU - Catalone, B. J. AU - Kish-Catalone, T. M. AU - Neely, E. B. AU - Budgeon, L. R. AU - Ferguson, M. L. AU - Stiller, C. AU - Miller, S. R. AU - Malamud, D. AU - Krebs, F. C. AU - Howett, M. K. PY - 2005 DA - 2005// TI - Comparative safety evaluation of the candidate vaginal microbicide C31G JO - Antimicrob Agents Chemother VL - 49 UR - https://doi.org/10.1128/AAC.49.4.1509-1520.2005 DO - 10.1128/AAC.49.4.1509-1520.2005 ID - Catalone2005 ER - TY - JOUR AU - Roddy, R. E. AU - Cordero, M. AU - Ryan, K. A. AU - Figueroa, J. PY - 1998 DA - 1998// TI - A randomized controlled trial comparing nonoxynol-9 lubricated condoms with silicone lubricated condoms for prophylaxis JO - Sex Transm Infect VL - 74 UR - https://doi.org/10.1136/sti.74.2.116 DO - 10.1136/sti.74.2.116 ID - Roddy1998 ER - TY - JOUR AU - Fichorova, R. N. AU - Bajpai, M. AU - Chandra, N. AU - Hsiu, J. G. AU - Spangler, M. AU - Ratnam, V. AU - Doncel, G. F. PY - 2004 DA - 2004// TI - Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives JO - Biol Reprod VL - 71 UR - https://doi.org/10.1095/biolreprod.104.029603 DO - 10.1095/biolreprod.104.029603 ID - Fichorova2004 ER - TY - JOUR AU - Fichorova, R. N. AU - Tucker, L. D. AU - Anderson, D. J. PY - 2001 DA - 2001// TI - The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission JO - J Infect Dis VL - 184 UR - https://doi.org/10.1086/322047 DO - 10.1086/322047 ID - Fichorova2001 ER - TY - JOUR AU - Noguchi, K. AU - Tsukumi, K. AU - Urano, T. PY - 2003 DA - 2003// TI - Qualitative and quantitative differences in normal vaginal flora of conventionally reared mice, rats, hamsters, rabbits, and dogs JO - Comparative medicine VL - 53 ID - Noguchi2003 ER - TY - JOUR AU - Costin, G. E. AU - Raabe, H. A. AU - Priston, R. AU - Evans, E. AU - Curren, R. D. PY - 2011 DA - 2011// TI - Vaginal irritation models: the current status of available alternative and in vitro tests JO - Alternatives to laboratory animals: ATLA VL - 39 ID - Costin2011 ER - TY - JOUR AU - Eckstein, P. AU - Jackson, M. C. AU - Millman, N. AU - Sobrero, A. J. PY - 1969 DA - 1969// TI - Comparison of vaginal tolerance tests of spermicidal preparations in rabbits and monkeys JO - Journal of reproduction and fertility VL - 20 UR - https://doi.org/10.1530/jrf.0.0200085 DO - 10.1530/jrf.0.0200085 ID - Eckstein1969 ER - TY - JOUR AU - Castle, P. E. AU - Hoen, T. E. AU - Whaley, K. J. AU - Cone, R. A. PY - 1998 DA - 1998// TI - Contraceptive testing of vaginal agents in rabbits JO - Contraception VL - 58 UR - https://doi.org/10.1016/S0010-7824(98)00059-6 DO - 10.1016/S0010-7824(98)00059-6 ID - Castle1998 ER - TY - JOUR AU - Pal, S. AU - Fielder, T. J. AU - Peterson, E. M. AU - de la Maza, L. M. PY - 1993 DA - 1993// TI - Analysis of the immune response in mice following intrauterine infection with the Chlamydia trachomatis mouse pneumonitis biovar JO - Infect Immun VL - 61 ID - Pal1993 ER - TY - JOUR AU - Cox, F. PY - 1982 DA - 1982// TI - Prevention of group B streptococcal colonization with topically applied lipoteichoic acid in a maternal-newborn mouse model JO - Pediatr Res VL - 16 UR - https://doi.org/10.1203/00006450-198210000-00003 DO - 10.1203/00006450-198210000-00003 ID - Cox1982 ER - TY - JOUR AU - Bourne, N. AU - Stegall, R. AU - Montano, R. AU - Meador, M. AU - Stanberry, L. R. AU - Milligan, G. N. PY - 2005 DA - 2005// TI - Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection JO - Antimicrob Agents Chemother VL - 49 UR - https://doi.org/10.1128/AAC.49.3.1181-1183.2005 DO - 10.1128/AAC.49.3.1181-1183.2005 ID - Bourne2005 ER - TY - JOUR AU - Milligan, G. N. AU - Bernstein, D. I. PY - 1997 DA - 1997// TI - Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract JO - Virology VL - 229 UR - https://doi.org/10.1006/viro.1997.8441 DO - 10.1006/viro.1997.8441 ID - Milligan1997 ER - TY - JOUR AU - Milligan, G. N. AU - Chu, C. F. AU - Young, C. G. AU - Stanberry, L. R. PY - 2004 DA - 2004// TI - Effect of candidate vaginally-applied microbicide compounds on recognition of antigen by CD4+ and CD8+ T lymphocytes JO - Biol Reprod VL - 71 UR - https://doi.org/10.1095/biolreprod.104.029215 DO - 10.1095/biolreprod.104.029215 ID - Milligan2004 ER - TY - JOUR AU - Lozenski, K. AU - Kish-Catalone, T. AU - Pirrone, V. AU - Rando, R. F. AU - Labib, M. AU - Wigdahl, B. AU - Krebs, F. C. PY - 2011 DA - 2011// TI - Cervicovaginal safety of the formulated, biguanide-based human immunodeficiency virus type 1 (HIV-1) inhibitor NB325 in a murine model JO - Journal of biomedicine & biotechnology VL - 2011 UR - https://doi.org/10.1155/2011/941061 DO - 10.1155/2011/941061 ID - Lozenski2011 ER - TY - JOUR AU - Haase, A. T. PY - 2010 DA - 2010// TI - Targeting early infection to prevent HIV-1 mucosal transmission JO - Nature VL - 464 UR - https://doi.org/10.1038/nature08757 DO - 10.1038/nature08757 ID - Haase2010 ER - TY - JOUR AU - Li, Q. AU - Estes, J. D. AU - Schlievert, P. M. AU - Duan, L. AU - Brosnahan, A. J. AU - Southern, P. J. AU - Reilly, C. S. AU - Peterson, M. L. AU - Schultz-Darken, N. AU - Brunner, K. G. PY - 2009 DA - 2009// TI - Glycerol monolaurate prevents mucosal SIV transmission JO - Nature VL - 458 UR - https://doi.org/10.1038/nature07831 DO - 10.1038/nature07831 ID - Li2009 ER - TY - JOUR AU - Pudney, J. AU - Quayle, A. J. AU - Anderson, D. J. PY - 2005 DA - 2005// TI - Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone JO - Biol Reprod VL - 73 UR - https://doi.org/10.1095/biolreprod.105.043133 DO - 10.1095/biolreprod.105.043133 ID - Pudney2005 ER - TY - JOUR AU - Cone, R. A. AU - Hoen, T. AU - Wong, X. AU - Abusuwwa, R. AU - Anderson, D. J. AU - Moench, T. R. PY - 2006 DA - 2006// TI - Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission JO - BMC Infect Dis VL - 6 UR - https://doi.org/10.1186/1471-2334-6-90 DO - 10.1186/1471-2334-6-90 ID - Cone2006 ER - TY - JOUR AU - Grimm, M. C. AU - Pavli, P. AU - Van de Pol, E. AU - Doe, W. F. PY - 1995 DA - 1995// TI - Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa–implications for pathogenesis JO - Clin Exp Immunol VL - 100 UR - https://doi.org/10.1111/j.1365-2249.1995.tb03667.x DO - 10.1111/j.1365-2249.1995.tb03667.x ID - Grimm1995 ER - TY - JOUR AU - Clahsen, T. AU - Schaper, F. PY - 2008 DA - 2008// TI - Interleukin-6 acts in the fashion of a classical chemokine on monocytic cells by inducing integrin activation, cell adhesion, actin polymerization, chemotaxis, and transmigration JO - J Leukoc Biol VL - 84 UR - https://doi.org/10.1189/jlb.0308178 DO - 10.1189/jlb.0308178 ID - Clahsen2008 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/2050-6511/13/9/prepub UR - http://www.biomedcentral.com/2050-6511/13/9/prepub ID - ref45 ER -