Figure 2From: Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety After a single exposure to N-9, severe toxicity was observed in the cervix. Mice were exposed once to unformulated N-9 at a concentration of 1% for the indicated durations. H&E-stained tissue sections (shown at 40× magnification) were assessed for vaginal (A, C, E, G) and cervical (B, D, F, H) epithelial toxicity and scored. The tissue damage score (see also Table1) is shown in the lower right corner of each panel.Back to article page