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Figure 4 | BMC Pharmacology and Toxicology

Figure 4

From: Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety

Figure 4

Cervical epithelial damage is still apparent after three daily exposures to N-9. Mice were exposed once daily over three days to unformulated 1% N-9 and sacrificed after the indicated post-exposure intervals following the third exposure. H&E-stained tissue sections (shown at 40× magnification) were assessed for vaginal (A, C, E, G) and cervical (B, D, F, H) epithelial toxicity and scored. The tissue damage score (see also Table1) is shown in the lower right corner of each panel.

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