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Figure 5 | BMC Pharmacology and Toxicology

Figure 5

From: Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety

Figure 5

Cervical epithelial damage after four exposures to N-9 is considerably less relative to the damage caused by a single exposure. Mice were exposed once daily for four days to unformulated 1% N-9 and sacrificed after the indicated post-exposure intervals following the fourth exposure. H&E-stained tissue sections (shown at 40× magnification) were assessed for vaginal (A, C, E, G) and cervical (B, D, F, H) epithelial toxicity and scored. The tissue damage score (see also Table1) is shown in the lower right corner of each panel.

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