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Figure 7 | BMC Pharmacology and Toxicology

Figure 7

From: Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety

Figure 7

N-9 exposure results in CD14 + cell infiltration on day 1 and, to a lesser extent, on day 4. Female Swiss Webster mice were exposed once to saline (A, B), once to unformulated 1% N-9 (C, D), or once daily to N-9 for four days (E, F). Mice were sacrificed after the indicated post-exposure intervals following the last exposure. Cervicovaginal tissue sections were stained immunohistochemically for the CD14 cell surface marker. Representative vaginal (A, C, E) and cervical (B, D, F) epithelial tissue sections are shown.

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