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Table 2 Average damage scores for cervical epithelial tissues exposed to N-9

From: Decreased cervical epithelial sensitivity to nonoxynol-9 (N-9) after four daily applications in a murine model of topical vaginal microbicide safety

  N-9 exposure duration
  10 min 2 h 4 h 8 h
Exposure 1/Day 1 1.3 ± 0.3 3.0 ± 0.0 3.0 ± 0.0 3.0 ± 0.0
Exposure 4/Day 4 0.0 ± 0.0 1.0 ± 0.0 1.7 ± 0.3 0.7 ± 0.3
P value, Day 1 vs. Day 4 0.016 <0.0001 0.016 0.002
  1. After the first or the fourth daily exposure to N-9, mice were sacrificed following the indicated post-exposure intervals. Scores (as described in Table1) were assigned to cervical tissue sections after multiple fields from three replicate mice at each time point within each exposure group were examined microscopically. Each value is expressed as an average score ± standard error. Significant differences between scores on Days 1 and 4 are indicated by p values less than 0.05 (as calculated by an unpaired Student’s t-test).