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Figure 12 | BMC Pharmacology and Toxicology

Figure 12

From: 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

Figure 12

Drug-induced changes in DNA methylation levels of repetitive elements. DNA methylation levels of the three classes of repeat sequences Alu, Satα, and Sat2, assessed by specific MethyLight assays, significantly decreased in Huh-7 cells upon treatment with AZA. The degree of hypomethylation correlated with drug concentration, with the exception of an increase in DNA methylation seen for all three repetitive elements at the 20 μM AZA concentration.

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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