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Table 1 Correlation between imaging and sequence-based methylcytosine levels

From: 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

 

3D-qDMI

MethyLight

AZA concentration

Normalized MeC intensity

Normalized Alu PMR value

Normalized Sat2 PMR value

Normalized Satα PMR value

No Drug

1.00

1.00

1.00

1.00

0.5 μM

0.72

0.92

0.86

0.37

1 μM

0.34

0.49

0.65

0.20

2.5 μM

0.26

0.51

0.69

0.42

5 μM

0.20

0.31

0.31

0.15

10 μM

0.14

0.17

0.45

0.22

20 μM

0.13

0.61

0.58

0.88

Correlation coefficient R*

0.96

0.89

0.86

  1. * Correlation coefficient R was calculated between the normalized MeC intensities measured by 3D-qDMI and normalized PMR values of the three classes of repetitive elements obtained by MethyLight, excluding the values for 20 μM of AZA.
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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