Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study

Table 1 Baseline characteristics of the cohort ^A

Characteristic	Guideline-recommended dosing (n = 113)^*	Lower dosing (n = 223)⁺	p-value
Male gender (%)	76%	81%	0.97
Age (years)	57 (46, 71)	54 (44, 63)	0.03
Height (cm)	172 (163, 178)	175 (168, 183)	<0.001
Weight (kg)	63 (57, 68)	88 (75, 104)	<0.001
Serum creatinine (mg/dl)	0.9 (0.7, 1.3)	0.9 (0.7, 1.2)	0.70
Creatinine clearance (ml/min)	71 (47, 104)	86 (66, 124)	<0.001
Charlson comorbidity index > 5	20%	13%	0.06
Length of hospital stay (days)	17 (9, 37)	18 (9, 32)	0.60
Intensive care unit resident	41%	41%	0.99
Pitt bacteremia ≥ 4	21%	22%	0.80
Concomitant nephrotoxin	50%	49%	0.85
Nephrotoxicity	22%	24%	0.74
Initial Vancomycin Dose (mg/kg/day)	32 (29, 36)	21 (17, 26)	<0.001

A = Results are presented as median (interquartile range) unless otherwise noted.
* = Vancomycin ≥ 30 mg/kg/day, ≥ 15 mg/kg/day for creatinine clearance of 30-50 ml/min.
+ = Vancomycin < 30 mg/kg/day, < 15 mg/kg/day for creatinine clearance of 30-50 ml/min.

ISSN: 2050-6511