|
Characteristic
|
Guideline-recommended dosing (n = 113)*
|
Lower dosing (n = 223)+
|
p-value
|
|---|
|
Male gender (%)
|
76%
|
81%
|
0.97
|
|
Age (years)
|
57 (46, 71)
|
54 (44, 63)
|
0.03
|
|
Height (cm)
|
172 (163, 178)
|
175 (168, 183)
|
<0.001
|
|
Weight (kg)
|
63 (57, 68)
|
88 (75, 104)
|
<0.001
|
|
Serum creatinine (mg/dl)
|
0.9 (0.7, 1.3)
|
0.9 (0.7, 1.2)
|
0.70
|
|
Creatinine clearance (ml/min)
|
71 (47, 104)
|
86 (66, 124)
|
<0.001
|
|
Charlson comorbidity index > 5
|
20%
|
13%
|
0.06
|
|
Length of hospital stay (days)
|
17 (9, 37)
|
18 (9, 32)
|
0.60
|
|
Intensive care unit resident
|
41%
|
41%
|
0.99
|
|
Pitt bacteremia ≥ 4
|
21%
|
22%
|
0.80
|
|
Concomitant nephrotoxin
|
50%
|
49%
|
0.85
|
|
Nephrotoxicity
|
22%
|
24%
|
0.74
|
|
Initial Vancomycin Dose (mg/kg/day)
|
32 (29, 36)
|
21 (17, 26)
|
<0.001
|
- A = Results are presented as median (interquartile range) unless otherwise noted.
- * = Vancomycin ≥ 30 mg/kg/day, ≥ 15 mg/kg/day for creatinine clearance of 30-50 ml/min.
- + = Vancomycin < 30 mg/kg/day, < 15 mg/kg/day for creatinine clearance of 30-50 ml/min.
