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Table 1 Baseline characteristics of the cohort A

From: Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study

Characteristic Guideline-recommended dosing (n = 113)* Lower dosing (n = 223)+ p-value
Male gender (%) 76% 81% 0.97
Age (years) 57 (46, 71) 54 (44, 63) 0.03
Height (cm) 172 (163, 178) 175 (168, 183) <0.001
Weight (kg) 63 (57, 68) 88 (75, 104) <0.001
Serum creatinine (mg/dl) 0.9 (0.7, 1.3) 0.9 (0.7, 1.2) 0.70
Creatinine clearance (ml/min) 71 (47, 104) 86 (66, 124) <0.001
Charlson comorbidity index > 5 20% 13% 0.06
Length of hospital stay (days) 17 (9, 37) 18 (9, 32) 0.60
Intensive care unit resident 41% 41% 0.99
Pitt bacteremia ≥ 4 21% 22% 0.80
Concomitant nephrotoxin 50% 49% 0.85
Nephrotoxicity 22% 24% 0.74
Initial Vancomycin Dose (mg/kg/day) 32 (29, 36) 21 (17, 26) <0.001
  1. A = Results are presented as median (interquartile range) unless otherwise noted.
  2. * = Vancomycin ≥ 30 mg/kg/day, ≥ 15 mg/kg/day for creatinine clearance of 30-50 ml/min.
  3. + = Vancomycin < 30 mg/kg/day, < 15 mg/kg/day for creatinine clearance of 30-50 ml/min.