Table 2 Univariable analysis of risk factors for nephrotoxicity
Variable | Odds ratio | 95% confidence interval |
|---|---|---|
Guideline-recommended vancomycin dosing | 0.91 | 0.53-1.56 |
Vancomycin duration > 15 days | 3.65 | 2.16-6.17 |
Weight greater than 100 kilograms | 2.08 | 1.18-3.67 |
Pitt Bacteremia Score of four or greater | 3.80 | 2.17-6.63 |
Vancomycin trough greater than 20 mcg/ml | 2.51 | 1.28-4.92 |
Age greater than 52 years | 2.40 | 1.38-4.15 |
Intensive care unit resident | 3.64 | 2.15-6.18 |
Concomitant nephrotoxin | 2.08 | 1.24-3.49 |
Male gender | 1.04 | 0.56-1.57 |
Charlson comorbidity index 5 or greater | 1.14 | 0.57-2.27 |
Baseline serum creatinine greater than 1.0 mg/dL | 0.94 | 0.56-1.57 |