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Table 2 Univariable analysis of risk factors for nephrotoxicity

From: Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study

Variable Odds ratio 95% confidence interval
Guideline-recommended vancomycin dosing 0.91 0.53-1.56
Vancomycin duration > 15 days 3.65 2.16-6.17
Weight greater than 100 kilograms 2.08 1.18-3.67
Pitt Bacteremia Score of four or greater 3.80 2.17-6.63
Vancomycin trough greater than 20 mcg/ml 2.51 1.28-4.92
Age greater than 52 years 2.40 1.38-4.15
Intensive care unit resident 3.64 2.15-6.18
Concomitant nephrotoxin 2.08 1.24-3.49
Male gender 1.04 0.56-1.57
Charlson comorbidity index 5 or greater 1.14 0.57-2.27
Baseline serum creatinine greater than 1.0 mg/dL 0.94 0.56-1.57