Volume dependence of airway resistance, tissue damping and tissue elastance during inflation to P
= 20 cmH
O and exhalation to functional residual capacity in two week old male (A, B, C) and female (D, E, F) offspring exposed in utero to drinking water containing 0 (control) or 100μg/L arsenic (mean). Tissue damping and tissue elastance at Prs = 20 cmH2O were significantly higher in male offspring exposed to 100μg/L arsenic compared to male controls. There was no effect of arsenic exposure on tissue mechanics in females and no effect of arsenic on airway resistance in either sex (* indicates significantly different to controls).