| |
[14C]-GSK2239633 (n = 6)
|
Total plasma drug-related radioactivity (n = 6)
|
|---|
|
Parameters
|
Geometric mean (95% CI)
|
Geometric mean (95% CI)*
|
|
Cmax (ng/mL)
|
7.451 (6.114, 9.079)
|
8.380 (7.503, 9.359)
|
|
AUC0–48 (ng.hour/mL)
|
4.420 (3.515, 5.556)
|
8.840 (7.538, 10.368)
|
|
AUC0–∞ (ng.hour/mL)
|
4.577 (3.606, 5.810)
|
11.418 (9.004, 14.480)
|
|
t½ (hour)1
|
13.5 [8.0–21.2]
|
31.6 [25.1–43.0]
|
|
CL (L/hour)
|
21.9 (17.2, 27.7)
|
8.8 (6.9, 11.1)
|
|
Vss (L)
|
119.0 (78.4, 182.0)
|
249.0 (200.0, 309.0)
|
|
Vd (L)
|
424.0 (275.0, 654.0)
|
399.0 (322.0, 494.0)
|
- * Concentrations are in ng GSK2239633 equiv/mL and ng GSK2239633 equiv.hour/mL for Cmax and AUC, respectively.
-
1 Median [range].
- CI: confidence interval; Cmax: maximum observed concentration; AUC0–48: area under the concentration-time curve from time 0 to 48 hours post-dose; AUC0–∞: area under the concentration-time curve from time 0 extrapolated to infinity; t½: half-life; CL: apparent clearance; Vss: volume of distribution at steady state; Vd: volume of distribution during terminal elimination phase.
