| [14C]-GSK2239633 (n = 6) | Total plasma drug-related radioactivity (n = 6) |
---|---|---|
Parameters | Geometric mean (95% CI) | Geometric mean (95% CI)* |
Cmax (ng/mL) | 7.451 (6.114, 9.079) | 8.380 (7.503, 9.359) |
AUC0–48 (ng.hour/mL) | 4.420 (3.515, 5.556) | 8.840 (7.538, 10.368) |
AUC0–∞ (ng.hour/mL) | 4.577 (3.606, 5.810) | 11.418 (9.004, 14.480) |
t½ (hour)1 | 13.5 [8.0–21.2] | 31.6 [25.1–43.0] |
CL (L/hour) | 21.9 (17.2, 27.7) | 8.8 (6.9, 11.1) |
Vss (L) | 119.0 (78.4, 182.0) | 249.0 (200.0, 309.0) |
Vd (L) | 424.0 (275.0, 654.0) | 399.0 (322.0, 494.0) |