Table 3 Summary of derived blood GSK2239633 pharmacokinetic parameters in the single oral dose study (geometric mean, 95% confidence interval)
| Â | GSK2239633 Dose | ||||||
|---|---|---|---|---|---|---|---|
Parameter | 150 mg(n = 8) | 300 mg (n = 8) | 600 mg (n = 8) | 900 mg (n = 8) | 1200 mg (n = 8) | 1500 mg (n = 8) | 1200 mg (Fed) (n = 8) |
AUC0–10 (ng.hour/mL) | 534 (430, 663) | 923 (695, 1227) | 1210 (1055, 1393) | 2060 (1552, 2741) | 1520 (1175, 1963) | 2560 (2026, 3234) | 4670 (3783, 5769) |
AUC0–t (ng.hour/mL) | 718 (518, 995) | 1560 (971, 2511) | 1970 (1563, 2492) | 3110 (2242, 4324) | 2330 (1499, 3611) | 4150 (3121, 5528) | 6520 (4264, 9980) |
AUC0–∞ (ng.hour/mL) | 420 | ND | ND | ND | ND | ND | 5180 (3101, 8654) |
%AUCex (%) | 13.7 | ND | ND | ND | ND | ND | 9.4 (3.6, 24.8) |
Cmax (ng/mL) | 178 (124, 256) | 353 (237, 526) | 538 (391, 739) | 869 (622, 1215) | 695 (476, 1016) | 1210 (778, 1889) | 1410 (1127, 1761) |
tmax (hour)1 | 1.5 [1.0–3.0] | 1.0 [1.0–3.0] | 1.0 [0.5–2.0] | 1.5 [0.5–3.0] | 1.0 [0.5–3.0] | 1.0 [0.5–4.0] | 3.0 [0.6–4.0] |