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Figure 1 | BMC Pharmacology and Toxicology

Figure 1

From: Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats

Figure 1

Nicotine affects the heart rate of anesthetized whole-animals. 10 μM Nicotine (Nic) induced a significant bradycardic response, while 1 μM D-tubocurarine reversed it, in both healthy (A) and chagasic (C) rats. Lower doses of Nic (i.e., 1 μM) have no effect on the heart rate of these animals. EKG results from healthy (B) and chagasic (D) rats, treated daily with 1 mg/Kg of reserpine for 3 days, showed a significant decrease of heart rate compared to untreated animals; however, 10 μM of nicotine has no bradycardic effect on reserpine-treated healthy (B) or chagasic (C) animals.

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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