Protocol Sequence | PQ interval | Aorta Pressure Wave | ||||||
---|---|---|---|---|---|---|---|---|
Healthy Hearts | Chagasic Hearts | Healthy Hearts | Chagasic Hearts | |||||
AV (msec) | % | AV (msec) | % | AV (mmHg) | % | AV (mmHg) | % | |
Basal | 46.8±2.5 | 100 | 54.2±2.6 @ | 100 | 14.1±2.3 | 100 | 14.4±1.4 | 100 |
Nic 1 μM A | 44.9±1.7 | 97.2±3.0 | 53.0±2.5 | 96.2±0.3 | 15.8±2.6 | 141.0±29.72 | 15.6±2.2 | 110.7±11.2 |
Nic 1 μM D | 47.1±2.4 | 101.7±4.3 | 53.3±3.0 | 95.7±1.3 | 13.6±1.9 | 124.7±28.72 | 13.3±1.5 | 96.0±10.0 |
Wash 1 | 49.9±1.9 | 100 | 53.7±2.2 | 100 | 11.6±1.6 | 100 | 12.9±1.5 | 100 |
Nic 10 μM A | 48.9±2.0 | 98.1±2.2 | 53.8±2.3 | 100.3±1.7 | 16.7±1.9* | 180.9±37.74 | 16.9±1.9* | 134.8±9.8 |
Nic 10 μM D | 45.4±2.2* | 90.7±2.2 | 54.2±2.5 | 104.6±2.0 @ | 14.6±1.6 | 159.5±31.96 | 13.6±1.3 | 112.8±8.7 |
Wash 2 | 47.9±1.9 | 100 | 55.8±2.6 | 100 | 11.8±1.2 | 100 | 12.6±1.5 | 100 |
Nic 100 μM A | 48.3±2.0 | 101.0±2.4 | 57.1±2.5 | 109.0±1.5 @ | 16.5±1.7* | 150.4±17.21 | 14.5±1.5 | 120.1±9.7 |
Nic 100 μM D | 48.7±2.0 | 101.4±2.9 | 54.5±2.6 | 100.5±1.2 | 12.8±1.6 | 107.1±5.75 | 13.4±1.5 | 112.7±12.6 |
Wash 3 | 48.1±2.1 | 100 | 51.2±2.6 | 100 | 12.9±1.4 | 100 | 13.1±1.2 | 100 |
MA | 47.4±2.0 | 99.6±3.8 | 53.0±2.4 | 103.4±1.7 | 11.7±1.5 | 90.5±8.13 | 12.3±1.3 | 95.3±6.4 |
MA+Nic 10 μM A | 48.2±2.3 | 100.3±2.1 | 52.7±2.05 | 104.3±1.1 | 12.5±2.3 | 92.7±9.64 | 11.4±1.3 | 88.7±6.0° |
MA+Nic 10 μM D | 48.6±2.9 | 101.2±2.8° | 53.6±2.4 | 102.8±0.4 | 12.4±1.6 | 94.4±7.88 | 11.4±1.4 | 87.7±6.6° |
Wash 4 | 46.6±2.4 | 100 | 53.9±2.1 | 100 | 10.3±1.5 | 100 | 11.5±1.3 | 100 |
DHβE | 47.4±2.4 | 101.7±1.7 | 55.4±2.5 | 107.8±0.5 @ | 12.4±2.1 | 121.9±15.10 | 10.7±1.2 | 95.4±3.7 |
DHβE+Nic 10 μM A | 49.0±2.6 | 105.5±1.8° | 55.8±2.5 | 104.7±0.6 | 11.2±1.8 | 110.0±12.80° | 11.0±1.2 | 98.5±4.5° |
DHβE+Nic 10 μM D | 48.8±1.9 | 105.6±2.2° | 55.6±2.3 | 106.8±0.7 | 10.4±1.7 | 99.8±8.64° | 10.8±1.2 | 96.3±4.4 |
Wash 5 | 48.4±2.1 | 100 | 55.8±2.6 | 100 | 10.0±1.9 | 100 | 10.1±0.9 | 100 |
αBGT | 50.6±2.1 | 104.9±2.9 | 55.3±2.5 | 97.2±0.9 @ | 7.7±1.4 | 84.3±7.33 | 10.6±1.0 | 104.2±3.8 |
αBGT+Nic 10 μM A | 50.3±1.9 | 104.4±1.9° | 56.0±2.9 | 81.3±3.6 | 9.4±1.7* | 96.5±5.52° | 8.9±1.2 | 99.0±5.2° @ |
αBGT+Nic 10 μM D | 49.4±1.8 | 102.6±2.4 | 57.4±2.6 | 106.6±1.7 | 10.3±2.1 | 105.2±12.35 | 9.7±1.2 | 95.4±3.8 @ |
Wash 6 | 50.3±2.1 | - | 57.8±2.7 | - | 10.4±1.0 | - | 9.3±1.7 | - |