TY - JOUR AU - Thanacoody, H. K. Ruben AU - Gray, Alasdair AU - Dear, James W. AU - Coyle, Judy AU - Sandilands, Euan A. AU - Webb, David J. AU - Lewis, Steff AU - Eddleston, Michael AU - Thomas, Simon HL AU - Bateman, D. Nicholas PY - 2013 DA - 2013/04/04 TI - Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP) JO - BMC Pharmacology and Toxicology SP - 20 VL - 14 IS - 1 AB - Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen. SN - 2050-6511 UR - https://doi.org/10.1186/2050-6511-14-20 DO - 10.1186/2050-6511-14-20 ID - Thanacoody2013 ER -