Skip to main content

Advertisement

Table 1 Manganese involvement in glutamine/glutamate-GABA cycle: disruption of glutamine and glutamate transporters

From: Role of astrocytes in manganese mediated neurotoxicity

Name of transporter   Changes down (down-regulation) mediated by manganese Cellular localization References
Glutamine transporter System    
SNAT3 System N mRNA and protein expression; function(uptake and efflux) astrocytes [67], [81]
SNAT2 System A mRNA and protein expression astrocytes [81]
ASCT2 System ASC protein expression; function (uptake and efflux) astrocytes [81]
LAT2 System L mRNA and protein expression; function (uptake) astrocytes endothelial cells [81]
Glutamine transporter
GLAST   protein expression; function (uptake) astrocytes [98], [103]
GLT-1   mRNA and protein expression; function (uptake) astrocytes [98], [103]