Table 3 Statistical comparisons of PK parameters of metformin, remogliflozin etabonate, remogliflozin, and GSK279782 with and without remogliflozin etabonate
Compound | PK parameter | Treatment comparison | Point estimate (GLSM Ratio) | 90% CI |
|---|---|---|---|---|
Metformin | AUC(0–12) [1] | MET + RE / MET | 1.05 | (0.98, 1.12) |
|  | Cmax | MET + RE / MET | 1.01 | (0.92, 1.10) |
Remogliflozin etabonate (prodrug) | AUC(0-last) | MET + RE / RE | 1.00 | (0.77, 1.29) |
|  | Cmax | MET + RE / RE | 0.85 | (0.54, 1.35) |
Remogliflozin (active entity) | AUC(0–12) | MET + RE / RE | 0.94 | (0.86, 1.04) |
|  | Cmax | MET + RE / RE | 0.79 | (0.60, 1.05) |
GSK279782 (active metabolite) | AUC(0–12) | MET + RE / RE | 0.96 | (0.92, 1.01) |
|  | Cmax | MET + RE / RE | 0.78 | (0.67, 0.91) |