Effects of CNX-011-67 treatment on blood glucose and insulin levels during glucose stimulated insulin secretion. (A) A total of 8 h glucose profile was measured in fed state and Glucose AUC was calculated. (B) After oral administration of glucose (2 g/kg), plasma glucose and insulin were measured. Also Glucose (D &F) and Insulin (C &E) AUC were calculated. (Black circle)-Lean control, (Black Diamond)-Vehicle control and (Black Triangle)-CNX-011-67 (5 mg/kg)). Data in all panels are mean ± SEM. Data in all panels are mean ± SEM (n = 10/group). Statistical comparison was conducted by One-way ANOVA with Dunnett’s post test correction to arrive at the significance level when compared with ZDF control. (*p < 0.05, ** p <0.01 and *** p < 0.001).