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Table 1 List of chorismate synthase inhibitors

From: Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria

Sl no

Pathogen name

Inhibitors name

IC50 nM

Ki nM

1

Escherichia coli

(6R)-6-Fluoro-EPSP

500 and 250000

3000

2

Salmonella typhimurium

2-(3-(-(S)-5-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-4-(3-hydroxy-4-methyl-2-nitrobenzamido)-5-oxopentylcarbamoyl)-phenoxy)acetic Acid

n/a

720000

2-(3-(3-((R)-3-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-2-(3-hydroxy-4-methyl-2-nitrobenzamido)-3-oxopropylthio) propylcarbamoyl)phenoxy)acetic Acid

n/a

2500000 ± 120000

N-((S)-6-Amino-1-((S)-1-amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-1-oxohexan-2-yl)-3-hydroxy-4-methyl-2-nitrobenzamide

n/a

5700000 ± 1000000

N-((S)-1-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-3-hydroxy-4-methyl-2-nitrobenzamide

n/a

6800000 ±2000000

3

Streptococcuspneumoniae

(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-pentoxyphenyl)methylidene]-1-benzofuran-3- one

220.0

n/a

(2E)-2-[(4-hexoxy-2-hydroxyphenyl)methylidene]-6, 7-dihydroxy-1-benzofuran-3-one

320.0

n/a

(2E)-2-[(4-butoxy-2-hydroxyphenyl)methylidene]-6, 7-dihydroxy-1-benzofuran-3-one

450.0

n/a

(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-propoxyphenyl)methylidene]-1-benzofuran-3- one

510.0

n/a

(2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(2-methylpropoxy)phenyl]methylidene]-1- benzofuran-3-one

580.0

n/a

ethyl 4-[4-[(E)-(6, 7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanoate

650.0

n/a

(2E)-6,7-dihydroxy-2-[(2-hydroxyphenyl)methylidene]-1-benzofuran-3-one

800.0

n/a

(2E)-6,7-dihydroxy-2-[(2-hydroxy-3-methoxyphenyl)methylidene]-1-benzofuran-3- one

800.0

n/a

(2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(4-hydroxybutoxy)phenyl]methylidene]-1- benzofuran-3-one

860.0

n/a

(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-propan-2-yloxyphenyl)methylidene]-1- benzofuran-3-one

1000.0

n/a

(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-phenylmethoxyphenyl)methylidene]-1- benzofuran-3-one

1000.0

n/a

4-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanenitrile

1100.0

n/a

4-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanoic acid

1100.0

n/a

(2E)-2-[(4-butoxyphenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one

1500.0

n/a

(2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(6-hydroxyhexoxy)phenyl]methylidene]-1- benzofuran-3-one

1600.0

n/a

(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-methoxyphenyl)methylidene]-1-benzofuran-3- one

1700.0

n/a

2-[2-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]phenoxy]acetic acid

1800.0

n/a

(2E)-6,7-dihydroxy-2-[(2-nitrophenyl)methylidene]-1-benzofuran-3-one

2000.0

n/a

(2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(3-hydroxypropoxy)phenyl]methylidene]-1- benzofuran-3-one

2500.0

n/a

2-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy]acetic acid

2600.0

n/a

(2E)-2-[[4-[ethyl(2-hydroxyethyl)amino]-2-methylphenyl]methylidene]-6, 7-dihydroxy-1-benzofuran-3-one

3400.0

n/a

(2E)-2-benzylidene-6,7-dihydroxy-1-benzofuran-3-one

3500.0

n/a

(2E)-6,7-dihydroxy-2-[(2-methylphenyl)methylidene]-1-benzofuran-3-one

4000.0

n/a

(2E)-6,7-dihydroxy-2-[(4-nitrophenyl)methylidene]-1-benzofuran-3-one

1700.0

n/a

(2E)-2-[[4-(diethylamino)-2-hydroxyphenyl]methylidene]-6,7-dihydroxy-1-benzofuran-3-one

5000.0

n/a

(2E)-6,7-dihydroxy-2-[(4-imidazol-1-ylphenyl)methylidene]-1-benzofuran-3-one

5100.0

n/a

(2E)-2-[(2-chlorophenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one

5200.0

n/a

(2E)-6,7-dihydroxy-2-[(4-pyrrolidin-1-ylphenyl)methylidene]-1-benzofuran-3-one

5500.0

n/a

(2E)-2-[(4-ethoxyphenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one

5800.0

n/a

(2E)-6,7-dihydroxy-2-[[4-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-3- one

7000.0

n/a

(2E)-2-[[4-(diethylamino)phenyl]methylidene]-6,7-dihydroxy-1-benzofuran-3-one

8500.0

n/a

ethyl 2-[4-[(E)-(6, 7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] acetate

10300.0

n/a

2-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]benzoic acid

10700.0

n/a

(2E)-6,7-dihydroxy-2-[(4-methoxyphenyl)methylidene]-1-benzofuran-3-one

14300.0

n/a

(2E)-6,7-dihydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one

15000.0

n/a

(2E)-6,7-dihydroxy-2-[[2-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-3- one

17300.0

n/a

4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]benzoic acid

24000.0

n/a

(2E)-2-[[4-(dimethylamino)phenyl]methylidene]-6, 7-dihydroxy-1-benzofuran-3-one

25900.0

n/a

(2E)-6,7-dihydroxy-2-[(4-morpholin-4-ylphenyl)methylidene]-1-benzofuran-3-one

>50000.0

n/a

(2E)-2-[(4-fluorophenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one

>60000.0

n/a

(2E)-6,7-dihydroxy-2-[(2-methoxyphenyl)methylidene]-1-benzofuran-3-one

>60000.0

n/a

  

[(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3, 4-trihydroxypentyl] dihydrogen phosphate

n/a

n/a