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Table 1 List of chorismate synthase inhibitors

From: Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria

Sl no Pathogen name Inhibitors name IC50 nM Ki nM
1 Escherichia coli (6R)-6-Fluoro-EPSP 500 and 250000 3000
2 Salmonella typhimurium 2-(3-(-(S)-5-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-4-(3-hydroxy-4-methyl-2-nitrobenzamido)-5-oxopentylcarbamoyl)-phenoxy)acetic Acid n/a 720000
2-(3-(3-((R)-3-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-2-(3-hydroxy-4-methyl-2-nitrobenzamido)-3-oxopropylthio) propylcarbamoyl)phenoxy)acetic Acid n/a 2500000 ± 120000
N-((S)-6-Amino-1-((S)-1-amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-1-oxohexan-2-yl)-3-hydroxy-4-methyl-2-nitrobenzamide n/a 5700000 ± 1000000
N-((S)-1-((S)-1-Amino-3-(3-chlorophenyl)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-3-hydroxy-4-methyl-2-nitrobenzamide n/a 6800000 ±2000000
3 Streptococcuspneumoniae (2E)-6,7-dihydroxy-2-[(2-hydroxy-4-pentoxyphenyl)methylidene]-1-benzofuran-3- one 220.0 n/a
(2E)-2-[(4-hexoxy-2-hydroxyphenyl)methylidene]-6, 7-dihydroxy-1-benzofuran-3-one 320.0 n/a
(2E)-2-[(4-butoxy-2-hydroxyphenyl)methylidene]-6, 7-dihydroxy-1-benzofuran-3-one 450.0 n/a
(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-propoxyphenyl)methylidene]-1-benzofuran-3- one 510.0 n/a
(2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(2-methylpropoxy)phenyl]methylidene]-1- benzofuran-3-one 580.0 n/a
ethyl 4-[4-[(E)-(6, 7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanoate 650.0 n/a
(2E)-6,7-dihydroxy-2-[(2-hydroxyphenyl)methylidene]-1-benzofuran-3-one 800.0 n/a
(2E)-6,7-dihydroxy-2-[(2-hydroxy-3-methoxyphenyl)methylidene]-1-benzofuran-3- one 800.0 n/a
(2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(4-hydroxybutoxy)phenyl]methylidene]-1- benzofuran-3-one 860.0 n/a
(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-propan-2-yloxyphenyl)methylidene]-1- benzofuran-3-one 1000.0 n/a
(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-phenylmethoxyphenyl)methylidene]-1- benzofuran-3-one 1000.0 n/a
4-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanenitrile 1100.0 n/a
4-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] butanoic acid 1100.0 n/a
(2E)-2-[(4-butoxyphenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one 1500.0 n/a
(2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(6-hydroxyhexoxy)phenyl]methylidene]-1- benzofuran-3-one 1600.0 n/a
(2E)-6,7-dihydroxy-2-[(2-hydroxy-4-methoxyphenyl)methylidene]-1-benzofuran-3- one 1700.0 n/a
2-[2-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]phenoxy]acetic acid 1800.0 n/a
(2E)-6,7-dihydroxy-2-[(2-nitrophenyl)methylidene]-1-benzofuran-3-one 2000.0 n/a
(2E)-6,7-dihydroxy-2-[[2-hydroxy-4-(3-hydroxypropoxy)phenyl]methylidene]-1- benzofuran-3-one 2500.0 n/a
2-[4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy]acetic acid 2600.0 n/a
(2E)-2-[[4-[ethyl(2-hydroxyethyl)amino]-2-methylphenyl]methylidene]-6, 7-dihydroxy-1-benzofuran-3-one 3400.0 n/a
(2E)-2-benzylidene-6,7-dihydroxy-1-benzofuran-3-one 3500.0 n/a
(2E)-6,7-dihydroxy-2-[(2-methylphenyl)methylidene]-1-benzofuran-3-one 4000.0 n/a
(2E)-6,7-dihydroxy-2-[(4-nitrophenyl)methylidene]-1-benzofuran-3-one 1700.0 n/a
(2E)-2-[[4-(diethylamino)-2-hydroxyphenyl]methylidene]-6,7-dihydroxy-1-benzofuran-3-one 5000.0 n/a
(2E)-6,7-dihydroxy-2-[(4-imidazol-1-ylphenyl)methylidene]-1-benzofuran-3-one 5100.0 n/a
(2E)-2-[(2-chlorophenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one 5200.0 n/a
(2E)-6,7-dihydroxy-2-[(4-pyrrolidin-1-ylphenyl)methylidene]-1-benzofuran-3-one 5500.0 n/a
(2E)-2-[(4-ethoxyphenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one 5800.0 n/a
(2E)-6,7-dihydroxy-2-[[4-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-3- one 7000.0 n/a
(2E)-2-[[4-(diethylamino)phenyl]methylidene]-6,7-dihydroxy-1-benzofuran-3-one 8500.0 n/a
ethyl 2-[4-[(E)-(6, 7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-3-hydroxyphenoxy] acetate 10300.0 n/a
2-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]benzoic acid 10700.0 n/a
(2E)-6,7-dihydroxy-2-[(4-methoxyphenyl)methylidene]-1-benzofuran-3-one 14300.0 n/a
(2E)-6,7-dihydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one 15000.0 n/a
(2E)-6,7-dihydroxy-2-[[2-(trifluoromethyl)phenyl]methylidene]-1-benzofuran-3- one 17300.0 n/a
4-[(E)-(6,7-dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]benzoic acid 24000.0 n/a
(2E)-2-[[4-(dimethylamino)phenyl]methylidene]-6, 7-dihydroxy-1-benzofuran-3-one 25900.0 n/a
(2E)-6,7-dihydroxy-2-[(4-morpholin-4-ylphenyl)methylidene]-1-benzofuran-3-one >50000.0 n/a
(2E)-2-[(4-fluorophenyl)methylidene]-6,7-dihydroxy-1-benzofuran-3-one >60000.0 n/a
(2E)-6,7-dihydroxy-2-[(2-methoxyphenyl)methylidene]-1-benzofuran-3-one >60000.0 n/a
   [(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3, 4-trihydroxypentyl] dihydrogen phosphate n/a n/a