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Table 3 Consumer adverse drug reactions (N) for nervous system medications in Europe by therapeutic group and seriousness (in parentheses), 2007 to 2011

From: Adverse drug reactions reported by consumers for nervous system medications in Europe 2007 to 2011

Therapeutic group (ATC level 2) Substance Total (serious)
Anaesthetics (N01) Articaine 1(1)
Bupivacaine 4(4)
Fentanyl 24(24)
Propofol 2(2)
Sevoflurane 2(2)
Sufentanil 4(4)
Total N01   37(37)
Analgesics (N02) Buprenorphine 24(24)
Codeine 14(14)
Diamorphine 3(3)
Dihydroergotamine 27(27)
Ergotamine 2(2)
Flupirtine 6(6)
Frovatriptan 2(2)
Hydromorphone 22(22)
Metamizole 20(20)
Methylergometrine 2(2)
Methysergide 25(25)
Morphine 6(6)
Oxycodone 56(56)
Paracetamol 42(42)
Phenazone 8(8)
Pizotifen 2(2)
Propyphenazone 7(7)
Sumatriptan 3(3)
Tilidine 11(10)
Tramadol 62(57)
Total N02   344(338)
Antiepileptic drugs (N03) Carbamazepine 142(142)
Clonazepam 13(13)
Gabapentin 53(53)
Lamotrigine 78(78)
Levetiracetam 2(2)
Oxcarbazepine 36(36)
Phenytoin 6(6)
Phenobarbital 4(4)
Pregabalin 1510(1510)
Topiramate 6(6)
Valproate 17(17)
Zonisamide 3(3)
Total N03   1870(1870)
Antiparkinson drugs (N04) Amantadine 9(9)
Apomorphine 45(45)
Benserazide 1(1)
Bromocriptine 26(26)
Cabergoline 1(1)
Carbidopa 43(43)
Entacapone 39(39)
Levodopa 44(44)
Piribedil 1(1)
Pramipexole 17(17)
Procyclidine 7(7)
Rasagiline 15(15)
Rotigotine 1(1)
Ropinirole 15(15)
Total N04   264(264)
Antipsychotics (N05A) Amisulpride 1(1)
Aripiprazole 19(19)
Bromperidol 8(8)
Chlorpromazine 7(7)
Chlorprothixene 23(23)
Clozapine 71(71)
Flupentixol 1(1)
Fluspirilene 2(2)
Haloperidol 12(12)
Levomepromazine 9(9)
Lithium 18(18)
Melperone 7(7)
Olanzapine 23(23)
Perphenazine 12(12)
Pipamperone 3(3)
Quetiapine 46(46)
Risperidone 37(37)
Sulpiride 7(7)
Thioridazine 6(6)
Tiapride 6(6)
Zuclopenthixol 21(21)
Total N05A   339(339)
Anxiolytics (N05B) Alprazolam 17(17)
Bromazepam 14(14)
Chlordiazepoxide 2(2)
Clorazepate 9(9)
Diazepam 19(19)
Lorazepam 74(74)
Oxazepam 8(8)
Total N05B   143(143)
Hypnotics and sedatives (N05C) Butalbital 5(5)
Clomethiazole 5(5)
Flunitrazepam 1(1)
Melatonin 4(4)
Zaleplon 3(3)
Zolpidem 14(14)
Zopiclone 12(12)
Total N05C   44(44)
Antidepressants (N06A) Agomelatine 29(29)
Amitriptyline 11(11)
Bupropion 7(7)
Citalopram 38(38)
Clomipramine 5(5)
Duloxetine 27(27)
Doxepin 1(1)
Escitalopram 25(25)
Fluoxetine 14(14)
Imipramine 1(1)
Mirtazapine 18(18)
Nortriptyline 6(6)
Opipramol 28(28)
Paroxetine 21(21)
Sertraline 22(22)
Trimipramine 7(7)
Venlafaxine 217(177)
Total N06A   477(437)
Psychostimulants (N06B) Caffeine 16(16)
Methylphenidate 61(61)
Total N06B   77(77)
Anti-dementia drugs (N06D) Memantine 2(2)
Rivastigmine 50(50)
Total N06D   52(52)
Parasympathomimetics (N07) Disulfiram 11(11)
Methylnaltrexone 2(2)
Nicotine 91(91)
Varenicline 1017(135)
Total N07   1121(239)
Total ATC group N   4766(2433)