Figure 13
From: Quantitation of small intestinal permeability during normal human drug absorption
Permeability versus octanol partition for charged solutes. Plot of the log of the permeability (cm/sec) versus the log of the octanol/water partition (log D) for the charged solutes in Additional file 1: Table 2. The solid line is the linear regression fit to the black points and the dashed line is the linear regression fit to the neutral solutes (Figure 10). The green points are cefixime and aztreonam which are substrate for the P-glycloprotein mediated efflux system.