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Table 1 Comparison ofaveraged” (AM) and dispersion convection (DC) absorption rates

From: Quantitation of small intestinal permeability during normal human drug absorption

DC Model AM Model
PDC (10-4 cm/sec) TD (min) TG(min) Fr. Absorb PAM(10-4 cm/sec) TG (min) Fr. Absorb
4.167 200 15 .987 4.77 17.2 .989
0.4167 200 15 0.600 0.493 18.56 0.604
0.04167 200 15 0.109 0.0514 19.76 0.111
0.004167 200 15 0.0119 0.00517 19.9 .012
4.167 1000 15 0.999 4.167 15 0.999
0.4167 1000 15 0.658 0.522 20.8 0.690
0.04167 1000 15 0.111 0.0645 29 0.121
0.004167 1000 15 0.0119 0.0067 30 0.0129
4.167 200 60 0.997 4.155 60.0 0.997
0.04167 200 60 0.109 0.062 86 0.107
4.167 1000 60 0.999 4.167 60.0 0.999
0.04167 1000 60 0.112 0.0879 114.5 0.121
  1. The theoretical time dependent absorption rate was generated for the DC parameters listed in the table (PDC = permeability, TD and TG = the dispersion and gastric emptying time constants). For all results, TF = 240 min, r = 1 cm, L = 700 cm. The DC “Fr. Absorb” is the resultant cumulative fraction absorbed. The AM parameters (permeability (PAM), TG and Fr. Absorb) were then adjusted to obtain the optimum fit to the DC absorption rate, similar to the procedure used to determine the experimental human small intestinal permeability by deconvolution.