Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2

Table 1 Specificity spectrum of coumestrol

Remaining kinase activity was determined in the presence of 10 μM coumestrol and 10 μM ATP and expressed as a percentage of the control without inhibitor. CK2, Casein kinase 2; CK1, Casein kinase 1; DYRK, Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase; HER2, Human epidermal growth factor receptor 2; MAP2K, Mitogen-activated protein kinase kinase; c-Met, c-Met receptor tyrosine kinase; VEGFR3, Vascular endothelial growth factor receptor 3; AKT, also known as protein kinase B (PKB); GSK, Glycogen synthase kinase; SRC, src Gene encoded non-receptor tyrosine kinase; PAK1, p21 Protein (Cdc42/Rac)-activated kinase 1; mTOR, Mammalian target of rapamycin; JAK, Janus kinase.

ISSN: 2050-6511