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Table 1 Specificity spectrum of coumestrol

From: Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2

Protein kinase Kinase activity %
CK2 0
CK1 119
DYRK1a 64
HER2 98
MAP2K 139
MET 101
AKT2 164
GSK3b 60
SRC 166
PAK1 129
mTOR 110
JAK2 53
  1. Remaining kinase activity was determined in the presence of 10 μM coumestrol and 10 μM ATP and expressed as a percentage of the control without inhibitor. CK2, Casein kinase 2; CK1, Casein kinase 1; DYRK, Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase; HER2, Human epidermal growth factor receptor 2; MAP2K, Mitogen-activated protein kinase kinase; c-Met, c-Met receptor tyrosine kinase; VEGFR3, Vascular endothelial growth factor receptor 3; AKT, also known as protein kinase B (PKB); GSK, Glycogen synthase kinase; SRC, src Gene encoded non-receptor tyrosine kinase; PAK1, p21 Protein (Cdc42/Rac)-activated kinase 1; mTOR, Mammalian target of rapamycin; JAK, Janus kinase.