Simulations of concentration-response relations for ATSM and EXOM. The parameters A
s and A
m are both kept at unity, while parameter L is 10-2 for all ATSM simulations in order to keep spontaneous activity insignificant and n for all EXOM simulations is = 1. Parameter c, the binding cooperativity constant, is varied in three steps by multiplying with a factor 103 from 10-3 to 103 as indicated in the panels. Parameter a is 5000 in all ATSM panels except for panels M-P where it is 500. For EXOM, parameter a is 50 in all panels except for panels Q-S where it is 5. For ATSM, parameter b is 1 in panels A-C, and 50 in the rest of panels G-V. For EXOM, parameter b is 0.01 in panels D-F, and 0.5 in the rest of panels J-Z. Parameter d is 1 in all panels except in panels T-Z where it is 3x10-3. All red curves have no alloster present, i.e., concentration of M = 0. M is varied in four steps. In panels A-F by a factor 100 from 2x10-4 to 2x102; in panels G-S by a factor 10 from 2x10-3 to 2x100; and in panels T-Z by a factor 10 from 2x10-1 to 2x102. Green curves with circles show the actual EC50 and the black circle represents the position of a limiting EC50 for M → ∞. The black circle falls outside the orthoster concentration range, 10-6 to 102, in panels S and Z with limiting EC50 values of 250 and 1304.