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Table 4 Parameter ratios from best-fits with ATSM and EXOM on three data sets

From: Allosteric transition: a comparison of two models

Model for analysis

Data-figure #

Parameters ratios from best fits to concentration-response curves for orthosters at three different concentrations of allosters

b

c

d

A m

ATSM

1

4.9

3.4

3.2

1.8

EXOM

46

1.9

3.0

2.6

ATSM

2

2.8

97

11

15

EXOM *

50

17

3.0

84

ATSM

3

1.6

9.2

16

1.5

EXOM

26

35

33

3.8

  1. Each single parameter ratio from best fits with ATSM or EXOM is adapted from analysis of three sets of data in the literature, data-figures 1 to 3, see last section in Methods for references. Each data set consists of four concentration-response curves, where one curve is an orthoster concentration-response curve without an alloster present and the three other curves are orthoster concentration-responses experimentally obtained at three different alloster concentrations.
  2. Parameters a and A s for both ATSM and EXOM were initially determined by model-fits to the basic orthoster concentration-response curves without an alloster present. Obtained values for a and A s were inserted in the model equations, which were then use for fitting to experimental data of the parameters b, c, d, and A m in the theories. Each number in the table is a ratio between best-fit values with the largest deviation between two of three results from fits for the single parameter to three concentration-response curves at different alloster concentrations.
  3. * For responses indicating spontaneous activity as in data-figure 2, evaluation by EXOM theory was performed by assuming a level of 9% spontaneous activity, thus fitting the EXOM distribution equation to 91% activity for all three alloster concentrations, 0.03, 0.1, and 0.3 μM ([37]). For ATSM used on data-figure 2, spontaneous activity was implemented by setting L/(1 + L) = 0.09. For data-figures 1 and 3a value of 0.01 was selected for L.
  4. For a more detailed explanation of how the presented parameter ratios are obtained, see last section in Methods.
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BMC Pharmacology and Toxicology

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