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Table 2 Parameter estimates of the anakinra effect on c-reactive protein concentrations in 22 SJIA patients (RESP = responders and RESI = patients with onset of “resistance” to treatment)

From: Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes

Parameter Estimate Relative standard error (%)
Baseline (mg/L)   
 RESP 141 27
 RESI 37.9 29
kTR (day-1) 0.042 27
C50 (mg/L) 0.03 37
kRESI (day-1) 0.0048 0.0018
Proportion of RESP 0.37 31
ηBASELINE.RESI 0.79 24
ηKTR 081 25
ϵ, mg/L (*) 0.39 6
  1. Key: Baseline, CRP level before treatment; k TR , transit time rate constant; C 50 , anakinra concentration that induces a 50% decrease of CRP level; k RESI , time rate constant of resistance appearance; η, between-subject variability; ϵ, constant residual variability, *log-additive model.