Figure 2

Causal reasoning networks support poor translatability of Amiodarone induced molecular mechanisms in vivo rat heart (A) to in vitro primary rat cardiomyoctes (B). Major differences can be seen in the lack of mechanism of action related hypotheses in vitro, predicted opposite directionality of the inflammation sub-networks, the size and composition of the tissue remodeling signal and different downstream responses (Apoptosis versus decreased cell cycle signaling). (Blue = predicted decrease, Yellow = predicted increase).