Figure 3
Causal reasoning networks support high translatability of dexamethasone induced molecular mechanisms from in vivo rat heart (A) to in vitro primary rat cardiomyocytes (B). The overview network illustrates hypotheses reflective of the mechanism of action such Dexamethasone + and glucocorticoid receptor NR3C1+ as well as an anti-inflammatory hypotheses. (Blue = predicted decrease, Yellow = predicted increase).