From: Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
PK parameters | Oral | i.v. |
---|---|---|
AUC (h.μg/ml) | 96.34 ± 10.53 | 44.35 ± 3.3 |
Tα (h) | 1.3 ± 0.43 | 0.11 ± 0.01 |
Tβ (h) | 3.1 ± 0.35 | 2.95 ± 0.11 |
Cmax (μg/ml) | 34.3 ± 1.94 | 163.9 ± 0.25 |
Vss (ml) | 21 ± 3 | 44 ± 4 |
CL (ml/h) | 21 ± 2 | 23 ± 2 |
Bioavailability | (96.43*50)/(44.35*100)*100 = 108% |