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Table 2 PK parameters of CR8 following single oral administration at 100 mg/kg and i.v. bolus administration of 50 mg/kg

From: Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice

PK parameters

Oral

i.v.

AUC (h.μg/ml)

96.34 ± 10.53

44.35 ± 3.3

Tα (h)

1.3 ± 0.43

0.11 ± 0.01

Tβ (h)

3.1 ± 0.35

2.95 ± 0.11

Cmax (μg/ml)

34.3 ± 1.94

163.9 ± 0.25

Vss (ml)

21 ± 3

44 ± 4

CL (ml/h)

21 ± 2

23 ± 2

Bioavailability

      (96.43*50)/(44.35*100)*100 = 108%

 
  1. AUC: Area under time plasma concentration curve.
  2. Tα: First elimination half-life.
  3. Tβ: Terminal elimination half-life.
  4. Cmax: Maximum reached concentration.
  5. Vss: Distribution volume at steady state.
  6. CL: Clearance.