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Table 2 PK parameters of CR8 following single oral administration at 100 mg/kg and i.v. bolus administration of 50 mg/kg

From: Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice

PK parameters Oral i.v.
AUC (h.μg/ml) 96.34 ± 10.53 44.35 ± 3.3
Tα (h) 1.3 ± 0.43 0.11 ± 0.01
Tβ (h) 3.1 ± 0.35 2.95 ± 0.11
Cmax (μg/ml) 34.3 ± 1.94 163.9 ± 0.25
Vss (ml) 21 ± 3 44 ± 4
CL (ml/h) 21 ± 2 23 ± 2
Bioavailability       (96.43*50)/(44.35*100)*100 = 108%  
  1. AUC: Area under time plasma concentration curve.
  2. Tα: First elimination half-life.
  3. Tβ: Terminal elimination half-life.
  4. Cmax: Maximum reached concentration.
  5. Vss: Distribution volume at steady state.
  6. CL: Clearance.