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Table 3 Potential factors influencing the prescription of oseltamivir by general practitioners to 3,293 influenza patients

From: Prescription of antiviral drugs during the 2009 influenza pandemic: an observational study using electronic medical files of general practitioners in the Netherlands

  Prescription of oseltamivir, n of patients (%) Univariate analysis Adjusted multilevel analysis
Variable No   Yes   OR (95% CI) OR (95% CI)
Gender        (not in model)
 Male 1,477 (47.5) 88 (48.6) ref -   
 Female 1,635 (52.5) 93 (51.4) 0.94 (0.70 to 1.28)   
Age at diagnosis         
 < 2 yrs 82 (2.6) 18 (9.9) 3.62 (2.07 to 6.36) 5.71 (3.01 to 10.80)
 2 to 14 yrs 972 (31.2) 32 (17.8) 0.54 (0.36 to 0.83) 0.70 (0.44 to 1.11)
 15 to 24 yrs 469 (15.1) 20 (11.0) 0.70 (0.43 to 1.16) 0.88 (0.51 to 1.52)
 25 to 59 yrs 1,321 (42.4) 80 (44.2) ref - ref -
 60 yrs or older 268 (8.6) 31 (17.1) 1.84 (1.19 to 2.87) 0.96 (0.58 to 1.57)
Co-morbidity at risk for complications         
 No 2,562 (82.3) 89 (49.2) ref - ref -
 Yes 550 (17.7) 92 (50.8) 4.82 (3.53 to 6.57) 4.94 (3.29 to 7.40)
Number of co-morbidities at risk        (not in model)
 0 2,562 (82.3) 89 (49.2) ref -
 1 443 (14.2) 70 (38.7) 4.55 (3.27 to 6.32)
 2 or 3 107 (3.4) 22 (12.1) 5.92 (3.57 to 9.81)
Specific co-morbidity at risk for complications*        (not in model)
 Cardiac disease 178 (5.7) 28 (15.6) 3.04 (1.97 to 4.68)
 Respiratory disease 290 (9.3) 54 (30.0) 4.17 (2.95 to 5.89)
 Diabetes mellitus 112 (3.6) 17 (9.4) 2.79 (1.64 to 4.77)
 Chronic renal insufficiency 9 (0.3) 3 (1.7) 5.84 (1.57 to 21.82)
 Reduced resistance against infections 59 (1.9) 9 (5.0) 2.72 (1.33 to 5.59)
 Children using salicylates 13 (0.4) 1 (0.6) 1.33 (0.17 to 10.24)
 Third trimester of pregnancy 12 (0.4) 3 (1.7) 4.38 (1.22 to 15.68)
Complicated course of illness         
 No 2,810 (90.3) 159 (87.8) ref - ref -
 Yes 302 (9.7) 22 (12.2) 1.29 (0.81 to 2.04) 0.95 (0.57 to 1.58)
Contacts with GP in 2009       - (not in model)
 <6 1,850 (59.4) 86 (47.5) ref  
 6 or more 1,262 (40.6) 95 (52.5) 1.62 (1.20 to 2.19)
Prescriptions in 2009 †         
 <8 2,300 (73.9) 92 (50.8) ref - ref -
 8 or more 812 (26.1) 89 (49.2) 2.74 (2.03 to 3.71) 1.36 (0.89 to 2.09)
  1. GP = general practitioner; OR = odds ratio; CI = confidence interval.
  2. *Reference group does not have the specific co-morbidity.
  3. †Excluding oseltamivir prescriptions.