Skip to main content

Table 4 Summary of PK parameters for piperacillin/tazobactam as compared with other studies

From: Pharmacokinetics of piperacillin/tazobactam in cancer patients with hematological malignancies and febrile neutropenia after chemotherapy

Parameter Present study Strayer et al. Shea et al. Auclair et al. Mattoes et al. Langaartner et al. Drusano et al. 1985 Drusano et al. 1989
C max (μg/mL) 319.3 ± 266.08 366.7 108.2 ± 31.7 SD 282.2 ± 57.7 231 ± 66 152 SD
C min (μg/mL) 13.5 ± 10.71 SD 27.6 ± 26.3 SD SD 11.5 ± 14.8 12 SD
VD (L/kg) 0.34 ± 0.18 SD 0.28 ± 0.07 0.12 0.2 34.6* 0.21 ± 0.14 0.13 ± 0.03
Ke (h –1 ) 0.57 ± 0.24 SD SD SD 0.86 ± 0.09 SD SD SD
CL (L/h) 9.93 ± 6.45 SD 8.6 ± 3.0 7.8 10.9 ± 2.5 10.23 8.31 ± 3.39 6.1 ± 2.54
t 1/2 (h) 1.38 ± 0.51 1.3 2.1 ± 1.2 0.9 0.81 ± 0.08 2.4 ± 1.2 1.47 ± 0.95 1.54 ± 0.42
AUC [0–∞) mg•h/L 434.28 ± 205.17 488.9 527.5 ± 216.1 290 380.4 ± 72.6 391 ± 183 635.3 ± 253.2 SD
Weight (kg) 56.4 ± 26.78 In vitro 79.6 ± 13.8 SD 69.8 ± 15.7 60 - 86 69.5 70.2 ± 29.05
  1. *Data shown in L.
  2. Mentioned on pages 7, 8 and 9.