|
Parameter
|
Present study
|
Strayer et al.
|
Shea et al.
|
Auclair et al.
|
Mattoes et al.
|
Langaartner et al.
|
Drusano et al. 1985
|
Drusano et al. 1989
|
|---|
|
C
max
(μg/mL)
|
319.3 ± 266.08
|
366.7
|
108.2 ± 31.7
|
SD
|
282.2 ± 57.7
|
231 ± 66
|
152
|
SD
|
|
C
min
(μg/mL)
|
13.5 ± 10.71
|
SD
|
27.6 ± 26.3
|
SD
|
SD
|
11.5 ± 14.8
|
12
|
SD
|
|
VD (L/kg)
|
0.34 ± 0.18
|
SD
|
0.28 ± 0.07
|
0.12
|
0.2
|
34.6*
|
0.21 ± 0.14
|
0.13 ± 0.03
|
|
Ke (h
–1
)
|
0.57 ± 0.24
|
SD
|
SD
|
SD
|
0.86 ± 0.09
|
SD
|
SD
|
SD
|
|
CL (L/h)
|
9.93 ± 6.45
|
SD
|
8.6 ± 3.0
|
7.8
|
10.9 ± 2.5
|
10.23
|
8.31 ± 3.39
|
6.1 ± 2.54
|
|
t
1/2
(h)
|
1.38 ± 0.51
|
1.3
|
2.1 ± 1.2
|
0.9
|
0.81 ± 0.08
|
2.4 ± 1.2
|
1.47 ± 0.95
|
1.54 ± 0.42
|
|
AUC
[0–∞)
mg•h/L
|
434.28 ± 205.17
|
488.9
|
527.5 ± 216.1
|
290
|
380.4 ± 72.6
|
391 ± 183
|
635.3 ± 253.2
|
SD
|
|
Weight (kg)
|
56.4 ± 26.78
|
In vitro
|
79.6 ± 13.8
|
SD
|
69.8 ± 15.7
|
60 - 86
|
69.5
|
70.2 ± 29.05
|
- *Data shown in L.
- Mentioned on pages 7, 8 and 9.
