Table 4 Summary of PK parameters for piperacillin/tazobactam as compared with other studies
Parameter | Present study | Strayer et al. | Shea et al. | Auclair et al. | Mattoes et al. | Langaartner et al. | Drusano et al. 1985 | Drusano et al. 1989 |
|---|---|---|---|---|---|---|---|---|
C max (μg/mL) | 319.3 ± 266.08 | 366.7 | 108.2 ± 31.7 | SD | 282.2 ± 57.7 | 231 ± 66 | 152 | SD |
C min (μg/mL) | 13.5 ± 10.71 | SD | 27.6 ± 26.3 | SD | SD | 11.5 ± 14.8 | 12 | SD |
VD (L/kg) | 0.34 ± 0.18 | SD | 0.28 ± 0.07 | 0.12 | 0.2 | 34.6* | 0.21 ± 0.14 | 0.13 ± 0.03 |
Ke (h –1 ) | 0.57 ± 0.24 | SD | SD | SD | 0.86 ± 0.09 | SD | SD | SD |
CL (L/h) | 9.93 ± 6.45 | SD | 8.6 ± 3.0 | 7.8 | 10.9 ± 2.5 | 10.23 | 8.31 ± 3.39 | 6.1 ± 2.54 |
t 1/2 (h) | 1.38 ± 0.51 | 1.3 | 2.1 ± 1.2 | 0.9 | 0.81 ± 0.08 | 2.4 ± 1.2 | 1.47 ± 0.95 | 1.54 ± 0.42 |
AUC [0–∞) mg•h/L | 434.28 ± 205.17 | 488.9 | 527.5 ± 216.1 | 290 | 380.4 ± 72.6 | 391 ± 183 | 635.3 ± 253.2 | SD |
Weight (kg) | 56.4 ± 26.78 | In vitro | 79.6 ± 13.8 | SD | 69.8 ± 15.7 | 60 - 86 | 69.5 | 70.2 ± 29.05 |