Table 2 Changes in the mean systolic blood pressure and QTc interval following each infusion of combretastatin A-4 phosphate (SE = Standard error)
| Ā | 1st infusion | 2nd infusion | 3rd infusion | 4th infusion | ||||
|---|---|---|---|---|---|---|---|---|
mmHg (SE) | QTc in Ī¼m (SE) | mmHg (SE) | QTc in Ī¼m (SE) | mmHg (SE) | QTc in Ī¼m (SE) | mmHg (SE) | QTc in Ī¼m (SE) | |
Prior to Infusion | 145 (4.8) | 411 (3.51) | 131 (3.38) | 406 (3.25) | 136 (4.78) | 412 (3.58) | 132 (7.11) | 415 (6.14) |
Hour 1 | 164 (7.9) | 419 (4.41) | 165 (5) | 405 (4.75) | 163 (9.48) | 416 (3.44) | 154 (4.84) | 417 (4.82) |
Hour 2 | 149 (6.66) | 430 (10.12) | 148 (5.53) | 427 (8.09) | 148 (5.32) | 428 (6.62) | 139 (6.56) | 425 (8.75) |
Hour 3 | 143 (6.31) | 424 (7.23) | 141 (2.95) | 422 (4.78) | 139 (5.33) | 428 (6.01) | 136 (7.8) | 424 (7.47) |
Hour 4 | 144 (7.6) | 426 (4.93) | 137 (4.5) | 426 (4.78) | 131 (5.75) | 424 (5.09) | 128 (6.63) | 423 (7.35) |
Hour 5 | 148 (9.7) | 423 (7.55) | 137 (5.08) | 429 (12.83) | 142 (3.62) | 423 (6.61) | 138 (5.72) | 421 (7.65) |