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Table 2 Changes in the mean systolic blood pressure and QTc interval following each infusion of combretastatin A-4 phosphate (SE = Standard error)

From: Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate

  1st infusion 2nd infusion 3rd infusion 4th infusion
mmHg (SE) QTc in μm (SE) mmHg (SE) QTc in μm (SE) mmHg (SE) QTc in μm (SE) mmHg (SE) QTc in μm (SE)
Prior to Infusion 145 (4.8) 411 (3.51) 131 (3.38) 406 (3.25) 136 (4.78) 412 (3.58) 132 (7.11) 415 (6.14)
Hour 1 164 (7.9) 419 (4.41) 165 (5) 405 (4.75) 163 (9.48) 416 (3.44) 154 (4.84) 417 (4.82)
Hour 2 149 (6.66) 430 (10.12) 148 (5.53) 427 (8.09) 148 (5.32) 428 (6.62) 139 (6.56) 425 (8.75)
Hour 3 143 (6.31) 424 (7.23) 141 (2.95) 422 (4.78) 139 (5.33) 428 (6.01) 136 (7.8) 424 (7.47)
Hour 4 144 (7.6) 426 (4.93) 137 (4.5) 426 (4.78) 131 (5.75) 424 (5.09) 128 (6.63) 423 (7.35)
Hour 5 148 (9.7) 423 (7.55) 137 (5.08) 429 (12.83) 142 (3.62) 423 (6.61) 138 (5.72) 421 (7.65)