Parameter | Group 1 (CRCL > 80 mL/min) n = 16 | Group 2 (CRCL 50–80 mL/min) n = 15 | Group 3 (CRCL 30–49 mL/min) n = 16 | Group 4a (CRCL < 30 mL/min) n = 16 |
---|---|---|---|---|
AUC, μg·h/L | 245.7 (51) | 347.5 (111) | 499.0 (110) | 523.0 (70.4)b |
Cmax, μg/L | 36.6 (17) | 44.2 (21) | 42.0 (32) | 40.56 (37.8)b |
AUCnorm, kg·h/L | 20.6 (56) | 29.4 (126) | 42.1 (109) | 29.7 (102) |
Cmax,norm, kg/L | 3.07 (17) | 3.48 (25) | 3.54 (30) | 2.97 (40) |
t½, h | 6.19 (50) | 10.1 (116) | 11.4 (103) | 9.52 (75) |