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Table 2 The effects of riociguat on midazolam pharmacokinetics (geometric means and coefficients of variation)

From: Pharmacokinetic interaction of ketoconazole, clarithromycin, and midazolam with riociguat

Midazolam/riociguat study

 

Midazolam (n=22)

Midazolam + riociguat 2.5 mg (n=22)

Parameter

GM

%CV

GM

%CV

AUC (µg·h/L)

91.1

34.3

98.2

37.0

Cmax (µg/L)

29.0

45.1

29.5

41.5

t1/2 (h)

4.5

35.9

4.3

34.9

  1. AUC, area under plasma concentration–time curve; Cmax, maximum riociguat plasma concentration; CV, coefficient of variation; GM, geometric mean; t1/2, elimination half-life.