Skip to main content

Table 1 Riociguat pharmacokinetics following a single oral dose of riociguat 2.5 mg in fed and fasted subjects (food-effects study)

From: Absorption behavior of riociguat: bioavailability, food effects, and dose-proportionality

Parametera Fasted (n=23) Fed (n=23) Estimated fed:fasted ratio (%) 90% CI %CV
Cmax (μg/L) 84.2 (44.7−152.7) 54.8 (28.9−91.4) 64.7 57.8–72.5 22.5
tmax (h) 1 (0.5−4.0) 4 (1.5−6.0)
AUC0-∞ (μgh/L) 572.2 (112.3−1300.0) 505.6 (113.3−1205.0) 88.3 82.2–95.0 14.3
  1. AUC, area under the plasma concentration–time curve; CI, confidence interval; Cmax, maximum riociguat plasma concentration; CV, coefficient of variation; tmax, time to reach Cmax.
  2. aData are mean (range) except tmax, which is median (range).