Table 1 Riociguat pharmacokinetics following a single oral dose of riociguat 2.5 mg in fed and fasted subjects (food-effects study)
From: Absorption behavior of riociguat: bioavailability, food effects, and dose-proportionality
Parametera | Fasted (n=23) | Fed (n=23) | Estimated fed:fasted ratio (%) | 90% CI | %CV |
|---|---|---|---|---|---|
Cmax (μg/L) | 84.2 (44.7−152.7) | 54.8 (28.9−91.4) | 64.7 | 57.8–72.5 | 22.5 |
tmax (h) | 1 (0.5−4.0) | 4 (1.5−6.0) | — | — | — |
AUC0-∞ (μg⋅h/L) | 572.2 (112.3−1300.0) | 505.6 (113.3−1205.0) | 88.3 | 82.2–95.0 | 14.3 |