From: Activation profile of cGMP-dependent protein kinase Iα
cNMP | pEC50 | Ka (µM) | Hill slope | Emax |
---|---|---|---|---|
cGMP** | 6.98 ± 0.04 | 0.11 | 1.71 ± 0.36 | 1.00 ± 0.04 |
2-MB-cGMP | 5.84 ± 0.13 | 1.45 | 1.12 ± 0.34 | 0.66 ± 0.03 |
cAMP** | 4.82 ± 0.11 | 15.13 | 1.28 ± 0.39 | 0.59 ± 0.05 |
6-MB-cAMP | 4.67 ± 0.06 | 21.38 | 1.35 ± 0.19 | 0.81 ± 0.03 |
cCMP** | 4.58 ± 0.14 | 26.30 | 1.84 ± 0.53 | 0.55 ± 0.04 |
4-MB-cCMP | 4.05 ± 0.10 | 89.13 | 1.10 ± 0.23 | 0.71 ± 0.06 |
Sp-cAMPS | 3.72 ± 0.61 | 190.55 | 1.38 ± 2.86 | 0.16 ± 0.01* |
Rp-cAMPS | n.d. | n.d. | n.d. | n.d. |
Sp-cCMPS | 3.53 ± 0.97 | 295.12 | 1.11 ± 1.34 | 0.17 ± 0.02* |
Rp-cCMPS | n.d. | n.d. | n.d. | n.d. |
cIMP** | 4.72 ± 0.04 | 19.05 | 1.54 ± 0.16 | 0.87 ± 0.02 |
cUMP** | 4.15 ± 0.04 | 70.79 | 0.85 ± 0.21 | 0.72 ± 0.03 |
cXMP** | 3.98 ± 0.04 | 104.71 | 2.06 ± 1.93 | 0.69 ± 0.03 |