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Table 1 Clinical severity scale of immediate reactions

From: Hypersensitivity to oxaliplatin: clinical features and risk factors

  According to ring and messmer [17] According to NCI-CTCAE
Grade Clinical signs  
1 Cutaneous-mucous signs Mild transient reaction with no infusion interruption
2 Cutaneous-mucous signs Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (antihistamines, corticosteroids, narcotics, IV fluids)
Cardiovascular signs (tachycardia, hypotension)
Respiratory signs
3 Cardiovascular collapse Prolonged reaction not rapidly responsive to symptomatic medication and/or brief interruption of infusion.
Bronchospam Recurrence of symptoms following initial improvement
Hospitalization indicated for clinical sequelae
4 Cardiac arrest Life-threatening consequences with urgent intervention indicated
5 - Death
  1. NCI-CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events.