Table 1 Clinical severity scale of immediate reactions
From: Hypersensitivity to oxaliplatin: clinical features and risk factors
According to ring and messmer [17] | According to NCI-CTCAE | |
|---|---|---|
Grade | Clinical signs | |
1 | Cutaneous-mucous signs | Mild transient reaction with no infusion interruption |
2 | Cutaneous-mucous signs | Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (antihistamines, corticosteroids, narcotics, IV fluids) |
Cardiovascular signs (tachycardia, hypotension) | ||
Respiratory signs | ||
3 | Cardiovascular collapse | Prolonged reaction not rapidly responsive to symptomatic medication and/or brief interruption of infusion. |
Bronchospam | Recurrence of symptoms following initial improvement | |
Hospitalization indicated for clinical sequelae | ||
4 | Cardiac arrest | Life-threatening consequences with urgent intervention indicated |
5 | - | Death |