Figure 1

Concentrations versus time plot of tobramycin with mean population prediction (solid line) and 90% prediction interval (dashed lines) after Osteoset® 10 g (left) or 20 g (right) in patients with normal renal function. Dose difference is almost fully compensated by different bioavailability, giving similar predictions. Superimposed points show the concentrations observed in 8 patients after 10 g and 4 patients after 20 g. v : first concentration below the limit of detection.