Simulated Yessotoxin studies using 4-level RSP designs with k-adjustment factor with fixed and increasing number of mice. The simulated Yessotoxin pathways obtained in the two 4-level RSP designs. The pathways obtained are shown by dashed line. The doses are given in μg/kg BW. The first design incorporates binomial outcome, k-adjustment factor, and 9 mice at each design level, where the ratios of dead mice are given in bracket. The second design incorporates binomial outcome, k-adjustment factor and increasing number of mice from 3 at the first level to 9 at the fourth, where the ratios of dead mice are given in square brackets [ ].