Figure 4
From: The development of response surface pathway design to reduce animal numbers in toxicity studies
The estimation of LD 50 using the optimised 3- and 4-level RSP designs. The optimised 3-level and 4-level RSP designs incorporate multinomial outcome, using k-adjustment factor and increasing number of mice with increasing design levels. The numbers of pathways are given along the x-axis, where the orange dots represent estimated value for 4-level RSP design and blue dots estimated value for 3-level RSP design.