Figure 5
From: The development of response surface pathway design to reduce animal numbers in toxicity studies
The obtained pathway in the in-vivo Azaspiracid-1 study using the optimised 4-level RSP design. The optimised 4-level RSP design incorporates multinomial outcome, using k-adjustment factor and increasing number of mice with increasing design levels, the pathway obtained is shown by dashed line. The doses are given in μg/kg BW and the numbers in the callouts represent the ratios of dead mice.